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CD19 Protein (AA 20-291) (Fc Tag,Biotin)

CD19 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Produktnummer ABIN2180717
  • Target Alle CD19 Proteine anzeigen
    CD19 (CD19 Molecule (CD19))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 20-291
    Spezies
    • 30
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Quelle
    • 25
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD19 Protein ist gelabelt mit Fc Tag,Biotin.
    Marke
    MABSol®,UltraLys
    Sequenz
    AA 20-291
    Spezifität
    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
    Produktmerkmale
    This protein carries a human IgG1 Fc fragment at the C-terminus. The protein has a calculated MW of 56.3 kDa. The protein migrates as 56-66 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
    Reinheit
    >95 % as determined by reduced SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD19 Protein
  • Kommentare

    A chemically labeled biotinylated protein with ultra sensitivity.
    The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
    Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Chen, Zhou, Zhang, Wang, Hu, Wang, Wang: "TREM1/Dap12-based CAR-T cells show potent antitumor activity." in: Immunotherapy, Vol. 11, Issue 12, pp. 1043-1055, (2019) (PubMed).

    MacLeod, Antony, Martin, Moser, Hekele, Wetzel, Brown, Triggiano, Hux, Pham, Bartsevich, Turner, Lape, Kirkland, Beard, Smith, Hirsch, Nicholson, Jantz, McCreedy: "Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 25, Issue 4, pp. 949-961, (2017) (PubMed).

  • Target
    CD19 (CD19 Molecule (CD19))
    Andere Bezeichnung
    CD19 (CD19 Produkte)
    Synonyme
    B4 Protein, CVID3 Protein, AW495831 Protein, CD19 Protein, CD19 molecule Protein, CD19 antigen Protein, CD19 Protein, Cd19 Protein
    Hintergrund
    B-lymphocyte antigen CD19, is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.
    Molekulargewicht
    56.3 kDa
    NCBI Accession
    NP_001761
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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