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Activin A Receptor Type II-Like 1 (ACVRL1) (AA 22-118) protein (His tag) Protein

ACVRL1 Spezies: Human Wirt: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE.
Produktnummer ABIN2180578
$286.00
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  • Target Alle ACVRL1 Proteine anzeigen
    ACVRL1
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 22-118
    Spezies
    • 9
    • 4
    • 2
    • 1
    Human
    Quelle
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ACVRL1 Protein ist gelabelt mit His tag.
    Sequenz
    AA 22-118
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.3 kDa. The protein migrates as 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >97 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    ACVRL1
    Andere Bezeichnung
    ALK-1 (ACVRL1 Produkte)
    Synonyme
    ACVRL1, vgb, alk1, zehn1109, hm:zehn1109, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, R-3, R3, SETHKIR, AI115505, AI427544, Acvrlk1, Alk1, activin A receptor like type 1, activin A receptor type II-like 1, activin A receptor, type II-like 1, ACVRL1, acvrl1, Acvrl1
    Hintergrund
    Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.
    Molekulargewicht
    11.5 kDa
    NCBI Accession
    NP_000011
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