PTPRN Protein (AA 687-979) (His tag)

Produktnummer ABIN2115481

Produktdetails

Target: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Protein-Typ: Recombinant

Proteineigenschaft: AA 687-979

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PTPRN Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human IA2/PTPRN (Met687-Gln979, N-6His)

Sequenz: MGSSHHHHHH SSGLVPRGSH MDISTGHMIL AYMEDHLRNR DRLAKEWQAL CAYQAEPNTC ATAQGEGNIK KNRHPDFLPY DHARIKLKVE SSPSRSDYIN ASPIIEHDPR MPAYIATQGP LSHTIADFWQ MVWESGCTVI VMLTPLVEDG VKQCDRYWPD EGASLYHVYE VNLVSEHIWC EDFLVRSFYL KNVQTQETRT LTQFHFLSWP AEGTPASTRP LLDFRRKVNK CYRGRSCPII VHCSDGAGRT GTYILIDMVL NRMAKGVKEI DIAATLEHVR DQRPGLVRSK DQFEFALTAV AEEVNAILKA LPQ

Produktmerkmale: Recombinant Human Receptor-type tyrosine-protein phosphatase-like N is produced with our E. coli expression system. The target protein is expressed with sequence (Met687-Gln979) of Human PTPRN fused with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Andere Bezeichnung: Receptor-Type Tyrosine-Protein Phosphatase-Like N (PTPRN Produkte)

Synonyme: IA-2 Protein, IA-2/PTP Protein, IA2 Protein, ICA512 Protein, R-PTP-N Protein, mIA-A Protein, mKIAA4064 Protein, Ia-2 Protein, fc43c04 Protein, ptprn Protein, wu:fc43c04 Protein, ia-2 Protein, ia2 Protein, ica512 Protein, r-ptp-n Protein, protein tyrosine phosphatase, receptor type N Protein, protein tyrosine phosphatase, receptor type, N Protein, protein tyrosine phosphatase, receptor type, Na Protein, protein tyrosine phosphatase, receptor type N L homeolog Protein, PTPRN Protein, Ptprn Protein, ptprna Protein, ptprn.L Protein

Hintergrund: Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Synonyms: Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512

Molekulargewicht: 35.6 kDa

UniProt: Q16849