Noggin (NOG) (AA 20-232) (Active) Protein

Details zu Produkt Nr. ABIN2018288
Proteinname
  • SYM1
  • SYNS1
  • nog-A
  • nog1
  • noggin-1
  • noggin
  • noggin
  • noggin L homeolog
  • noggin protein
  • NOG
  • Nog
  • nog.L
  • noggin
Proteineigenschaft
AA 20-232
12
3
3
2
1
1
1
Spezies
Maus
35
16
8
3
2
2
1
1
Quelle
CHO Cells
38
7
6
4
2
2
2
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Optionen
Produktmerkmale ED50< 60 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.
Reinheit > 95 % as analyzed by SDS-PAGE.
Endotoxin-Niveau < 0.2 EU/μg, determined by LAL method.
Proteinname
Hintergrund Noggin, also known as NOG, is a homodimeric glycoprotein that binds to and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors.Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients that regulate cellular responses in a concentration-dependent manner.
Synonyms: NOG
Molekulargewicht 29-31 kDa, observed by reducing SDS-PAGE.
UniProt P97466
Pathways Stem Cell Maintenance, Tube Formation
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstituted in ddH2O or PBS at 100 μg/mL.
Buffer Lyophilized after extensive dialysis against PBS.
Lagerung -80 °C
Informationen zur Lagerung Lyophilized recombinant murine Nogginremains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Nogginshould be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
Haltbarkeit 6 months
Bilder des Herstellers
SDS-PAGE (SDS) image for Noggin (NOG) (AA 20-232) (Active) protein (ABIN2018288) 2 μg of Noggin, Mouse was resolved with SDS-PAGE under reducing (R) and non-reducing ...
Activity Assay (AcA) image for Noggin (NOG) (AA 20-232) (Active) protein (ABIN2018288) Noggin, Mouse inhibit BMP-4 induced alkaline phosphatase production in ATDC-5 cells i...
Produkt verwendet in: Bohnenpoll, Wittern, Mamo, Weiss, Rudat, Kleppa, Schuster-Gossler, Wojahn, Lüdtke, Trowe, Kispert: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, 2017 (PubMed).

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