Neurotrophin 4 Protein (NTF4) (AA 81-210)

Produktnummer ABIN2018284

Produktdetails

Target: Neurotrophin 4 (NTF4)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 81-210

Spezies: Human

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ED50 < 5.0 μg/mL, measured by a cell proliferation assay using C6 cells, corresponding to a specific activity of > 2.0x 102 units/mg.
AA 81-210, expressed with an N-terminal Met.

Reinheit: > 95 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: < 0.3 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in 50 mM acetic acid or ddH2O at 50 μg/mL.

Buffer: Lyophilized after extensive dialysis against 50 mM acetic acid.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human Neurotrophin-4 (rhNT-4) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhNT-4 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Neurotrophin 4 (NTF4)

Andere Bezeichnung: Neurotrophin-4 (NT-4) (NTF4 Produkte)

Synonyme: NTF5 Protein, GLC10 Protein, GLC1O Protein, NT-4 Protein, NT-4/5 Protein, NT-5 Protein, NT4 Protein, NT5 Protein, NT4P Protein, Ntf5 Protein, 2900040K06Rik Protein, AI462899 Protein, NT4/5 Protein, Ntf-5 Protein, Ntf4 Protein, neurotrophin 4 Protein, neurotrophin 5 Protein, NTF4 Protein, Ntf4 Protein, ntf4 Protein, Ntf5 Protein

Hintergrund: Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-3. Human NT-4 shares 48 - 52 % aa sequence identity with human beta-NGF, BDNF, and NT-3.Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. NT-4 is expressed highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons.Recombinant human Neurotrophin-4 (rhNT-4) produced in E.coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chains of 131 amino acids. A fully biologically active molecule, rhNT-4 has a molecular mass of 28.1 kDa analyzed by reducing SDS-PAGE.
Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)

Molekulargewicht: 28.1 kDa, a noncovalently linked homodimer,of two 14.0 kDa polypeptide monomers.

UniProt: P34130

Pathways: RTK Signalweg