Neuregulin 1 (NRG1) (AA 2-246), (N-Term) (Active) protein (Fc Tag,ECD)

Details zu Produkt Nr. ABIN2004420, Anbieter: Anmelden zum Anzeigen
Proteinname
  • GDF-15
  • MIC-1
  • MIC1
  • NAG-1
  • PDF
  • PLAB
  • PTGFB
  • 6030402G23Rik
  • ARIA
  • D230005F13Rik
  • GGF
  • GGFII
  • HRG
  • HRGalpha
  • Hgl
  • NDF
  • SMDF
  • GGF2
  • HGL
  • HRG1
  • HRGA
  • MST131
  • NRG-1
  • heregulin
  • nrg1-A
  • pro-neuregulin-1
  • NRG1
  • wu:fm70e01
  • DKFZp459A1838
  • AI265597
  • AW413091
  • D16jh2
  • D18020
  • Hprg
  • Hrgp
  • growth differentiation factor 15
  • neuregulin 1
  • neuregulin 1 L homeolog
  • histidine-rich glycoprotein
  • GDF15
  • Nrg1
  • NRG1
  • nrg1.L
  • nrg1
  • Hrg
Proteineigenschaft
N-Term, AA 2-246
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Spezies
Human
37
8
5
3
1
Quelle
Human Cells
28
14
6
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses Neuregulin 1 Protein ist gelabelt mit Fc Tag,ECD.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human NRG1/mFc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Protein Structure: A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
Predicted N-Term: Asp
Reinheit > 88 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment 1. Measured by its ability to bind with human ErbB4-His in a functional ELISA.
2. Measured by its ability to bind with human ErbB3-His in a functional ELISA.
Hintergrund Synonyms: ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,Neuregulin 1,NRG1-IT2,SMDF
Molekulargewicht 53.4 kDa, 67 kDa
UniProt Q02297
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Neuregulin 1 (NRG1) (AA 2-246), (N-Term) (Active) protein (Fc Tag,ECD) (ABIN2004420) Neuregulin 1 (NRG1) (AA 2-246), (N-Term) (Active) protein (Fc Tag,ECD)
Allgemeine Veröffentlichungen Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: "Identification of heregulin, a specific activator of p185erbB2." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1205-10, 1992 (PubMed).