Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 31-242) (Active) protein (Fc Tag)

Details zu Produkt Nr. ABIN2003474, Anbieter: Anmelden zum Anzeigen
Proteinname
  • DKK-1
  • SK
  • dkk1
  • dkk
  • dkk-1
  • xdkk1
  • Xdkk-1
  • Dickkopf1
  • dickkopf-1
  • mdkk-1
  • dkk1-A
  • dickkopf WNT signaling pathway inhibitor 1
  • dickkopf-related protein 1
  • dickkopf WNT signaling pathway inhibitor 1b
  • dickkopf protein
  • dickkopf WNT signaling pathway inhibitor 1 S homeolog
  • DKK1
  • Dkk1
  • LOC100228789
  • dkk1b
  • dkk1
  • dickkopf
  • dkk1.S
Proteineigenschaft
AA 31-242
8
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Spezies
Human
36
9
2
2
Quelle
Human Cells
15
12
4
3
3
3
2
2
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses DKK1 Protein ist gelabelt mit Fc Tag.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human DKKL1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 472 amino acids and has a predicted molecular mass of 52.4 kDa. rhDKKL1/Fc monomer migrates as an approximately 60 kDa protein in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the secreted form of human DKKL1 (Q9UK85) (Ala 31-Leu 242) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Predicted N-Term: Glu
Reinheit > 70 % as determined by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is typically 5-15 μg/ml.
Hintergrund Synonyms: CT34,SGY,SGY-1,SGY1
Molekulargewicht 52.4 kDa, 60 kDa
UniProt Q9UK85
Pathways WNT Signalweg, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 31-242) (Active) protein (Fc Tag) (ABIN2003474) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 31-242) (Active) protein (Fc Tag)
Allgemeine Veröffentlichungen Kohn, Kaneko, DePamphilis: "DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 516-22, 2005

Kohn, Kaneko, DePamphilis: "DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 516-22, 2005 (PubMed).

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