Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 2-321) (Active) protein (His tag)

Details zu Produkt Nr. ABIN2002547, Anbieter: Anmelden zum Anzeigen
Proteinname
  • PTPN1
  • PTP1B
  • PTP-1B
  • PTP-HA2
  • Ptp
  • ptp1b
  • wu:fk54h03
  • CPTP1
  • protein tyrosine phosphatase, non-receptor type 1
  • protein tyrosine phosphatase, non-receptor type 1 L homeolog
  • PTPN1
  • Ptpn1
  • ptpn1
  • ptpn1.L
Proteineigenschaft
AA 2-321
2
2
2
2
1
1
1
Spezies
Human
16
1
1
1
Quelle
Escherichia coli (E. coli)
8
2
2
2
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Aufreinigungstag / Konjugat
Dieses PTPN1 Protein ist gelabelt mit His tag.
Applikation
Functional Studies (Func), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktmerkmale The recombinant human PTPN1consisting of 327 amino acids and has a calculated molecular mass of 38 kDa.

Protein Structure: A DNA sequence encoding the human PTPN1 (NP_002818.1) (Glu 2-Asn 321) was expressed, with a polyhistide tag at the N-terminus.
Predicted N-Term: Met
Reinheit > 95 % as determined by SDS-PAGE
Biological Activity Comment Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor (aa988-998) phosphopeptide substrate, R&D Systems, Catalog # ES006.
The specific activity is > 15 nmoles/min/μg.
Proteinname
Hintergrund Synonyms: PTP1B,PTPN1
Molekulargewicht 38 kDa
NCBI Accession NP_002818
Pathways TLR Signalweg, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Supplied as sterile 10 mM Hepes, 150 mM NaCl, 1 mM DTT, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handhabung Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Lagerung -20 °C,-80 °C
Informationen zur Lagerung Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: Liquid. It is shipped out with blue ice.
Haltbarkeit 12 months
Bilder des Herstellers
 image for Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 2-321) (Active) protein (His tag) (ABIN2002547) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 2-321) (Active) protein (His tag)
Allgemeine Veröffentlichungen Liang, Lee, Liang, Lawrence, Zhang: "The role of protein-tyrosine phosphatase 1B in integrin signaling." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24857-63, 2005

Liang, Lee, Liang, Lawrence, Zhang: "The role of protein-tyrosine phosphatase 1B in integrin signaling." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24857-63, 2005 (PubMed).

Haj, Verveer, Squire, Neel, Bastiaens: "Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum." in: Science (New York, N.Y.), Vol. 295, Issue 5560, pp. 1708-11, 2002 (PubMed).

Moeslein, Myers, Landreth: "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B." in: The Journal of biological chemistry, Vol. 274, Issue 38, pp. 26697-704, 1999 (PubMed).

Frangioni, Beahm, Shifrin, Jost, Neel: "The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence." in: Cell, Vol. 68, Issue 3, pp. 545-60, 1992 (PubMed).

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