Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) (Active) Protein

Details zu Produkt Nr. ABIN1981648, Anbieter: Anmelden zum Anzeigen
Proteinname
  • AWD
  • GAAD
  • NB
  • NBS
  • NDKA
  • NDPK-A
  • NDPKA
  • NM23
  • NM23-H1
  • AL024257
  • NM23-M1
  • NM23A
  • NDPK-Z1
  • NM23-B
  • NM23-Z1
  • ndpkz1
  • nm23b
  • nme1
  • nme2
  • nme2b1
  • NME1
  • NME1-NME2
  • NM23-C1
  • ndpk-b
  • ndpkb
  • nm23-h2
  • nm23ndk
  • puf
  • NBR-A
  • NBR-B
  • NME1-1
  • nm23ndk-a
  • NDK I
  • NDPK I
  • T30A10.80
  • T30A10_80
  • NDP kinase I
  • NME/NM23 nucleoside diphosphate kinase 1
  • NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
  • non-metastatic cells 1, protein (NM23A) expressed in
  • NME/NM23 nucleoside diphosphate kinase 2 S homeolog
  • NME/NM23 nucleoside diphosphate kinase 2 L homeolog
  • nucleoside diphosphate kinase
  • nucleoside diphosphate kinase 1
  • NME1
  • Nme1
  • nme2b.1
  • nme2.S
  • nme2.L
  • LOC547870
  • NDPK1
  • LOC107790563
Proteineigenschaft
AA 1-152
9
8
3
2
2
2
2
2
1
1
1
Spezies
Human
22
3
2
2
1
1
1
1
1
1
Quelle
Escherichia coli (E. coli)
22
9
2
2
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
SDS-PAGE (SDS)
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Sequenz MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE
Produktmerkmale Molecule Information: 17.1 kDa (152 aa, 1-152 aa)
Reinheit ≥95 % by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity Comment Specific activity is > 180 unit/ml, in which one unit will convert 1.0 μmole each of TDP and ATP to TTP and ADP per minute at pH 7.6 at 25°C in a coupled system with PK/LDH.
Unit Definition One unit will convert 1.0 μmole each of TDP and ATP to TTP and ADP per minute at pH 7.6 at 25°C in a coupled system with PK/LDH.
Hintergrund Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas. Recombinant human NME1 was expressed in E.coli and purified by using conventional chromatography techniques.

Alternative Names: Non-metastatic cells 1, Nucleoside diphosphate kinase A, NDP kinase A, AWD, GAAD, NB, NBS, NDPK-A, NM23, NM23-H1.
Molekulargewicht 17.1 kDa
Gen-ID 4830
UniProt P15531
Pathways Apoptose, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer 1 mg/mL solution in 20 mM Tris-HCl buffer ( pH 7.5) containing 10 % glycerol and 1 mM DTT
Konservierungs-mittel Dithiothreitol (DTT)
Vorsichtsmaßnahmen This product contains dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Centrifuge the vial prior to opening.
Lagerung -20 °C
Haltbarkeit 12 months
Bilder des Herstellers
SDS-PAGE (SDS) image for Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) (Active) protein (ABIN1981648) Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) (Active) protein
Haben Sie etwas anderes gesucht?