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ESR2 Protein (Estrogen Receptor 2) (AA 1-323) (His tag)

ESR2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1692101
$385.00
Zzgl. Versandkosten $45.00
Lieferung in 4 Werktagen
  • Target Alle ESR2 Proteine anzeigen
    ESR2 (Estrogen Receptor 2 (ESR2))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 1-323
    Spezies
    • 6
    • 3
    • 2
    • 1
    • 1
    Human
    Quelle
    • 5
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses ESR2 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human Estrogen Receptor β/ERβ/NR3A2 (N-6His)
    Sequenz
    MGSSHHHHHH SSGLVPRGSH MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK LADKELVHMI SWAKKIPGMR GNA
    Produktmerkmale
    Recombinant Human Estrogen Receptor Beta/ESR2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala323) of Human ESR2 fused with a 6His tag at the N-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 50 mM TrisHCl, pH 8.0.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Haltbarkeit
    3 months
  • Target
    ESR2 (Estrogen Receptor 2 (ESR2))
    Andere Bezeichnung
    ESR2 (ESR2 Produkte)
    Synonyme
    ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ER[b]1, zfER-beta1, zfER[b]1, erb2, CERB, ERB, erb, esrb, estrb, nr3a2, ERbeta, er-beta, esr-beta, ESR2, ERBETA, er, ER-beta, ER[b], Estrb, ER[b]2, ER[b]a, zfER[b]2, zfER-beta2, Erb2, esr2, erbeta, Esr2, ERBeta2, estrogen receptor 2, estrogen receptor 2b, estrogen receptor beta 2, estrogen receptor 2 (beta), estrogen receptor 2a, estrogen receptor beta, ESR2, esr2b, erb2, esr2, Esr2, esr2a, erbeta
    Sub Type
    Fusionprotein
    Hintergrund
    Estrogen Receptor Beta (ESR2) is a nuclear protein that belongs to the nuclear hormone receptor family of NR3 subfamily. It contains one nuclear receptor DNA-binding domain and is expressed in many tissues at a lower level. ESR2 is a nuclear hormone receptor. It binds estrogens with an affinity similar to that of ESR1 and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
    Alternative Names: Estrogen Receptor Beta, ER-Beta, Nuclear Receptor Subfamily 3 Group A Member 2, ESR2, ESTRB, NR3A2
    Molekulargewicht
    38.1 kDa
    Pathways
    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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