LTBR Protein (AA 28-218) (Fc Tag)

Produktnummer ABIN1691786

Produktdetails

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Protein-Typ: Recombinant

Proteineigenschaft: AA 28-218

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses LTBR Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse Lymphotoxin β Receptor/LTBR/TNFRSF3/TNFRrp (C-Fc)

Sequenz: SQPQLVPPYR IENQTCWDQD KEYYEPMHDV CCSRCPPGEF VFAVCSRSQD TVCKTCPHNS YNEHWNHLST CQLCRPCDIV LGFEEVAPCT SDRKAECRCQ PGMSCVYLDN ECVHCEEERL VLCQPGTEAE VTDEIMDTDV NCVPCKPGHF QNTSSPRARC QPHTRCEIQG LVEAAPGTSY SDTICKNPPE PVDDIEGRMD EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK

Produktmerkmale: Recombinant Mouse Tumor necrosis factor receptor superfamily member 3/TNFRSF3 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser28-Pro218) of Mouse TNFRSF3 fused with a FC tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 5 months

Antigendetails

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Andere Bezeichnung: TNFRSF3 (LTBR Produkte)

Synonyme: AI256028 Protein, CD18 Protein, LTbetaR Protein, Ltar Protein, TNF-R-III Protein, TNFCR Protein, TNFR-RP Protein, TNFR2-RP Protein, TNFRrp Protein, Tnfbr Protein, Tnfrsf3 Protein, D12S370 Protein, LT-BETA-R Protein, TNFR3 Protein, TNFRSF3 Protein, lymphotoxin beta receptor Protein, lymphotoxin B receptor Protein, Ltbr Protein, LTBR Protein

Sub Type: Fusionprotein

Hintergrund: It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
Alternative Names: Tumor necrosis factor receptor superfamily member 3 ，Lymphotoxin-beta receptor ，Ltbr, Tnfcr， Tnfrsf3

Molekulargewicht: 48.7 kDa

UniProt: P50284

Pathways: NF-kappaB Signalweg