CCM2 Protein (His tag)

Produktnummer ABIN1589765

Produktdetails

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CCM2 Protein ist gelabelt mit His tag.

Sequenz: MGSSHHHHHHSSGLVPRGSHMEEEGKKGKKPGIVSPFKRV FLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQ LPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVV YTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKET YEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQ DYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQ LYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGI ITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE WDRMISDISSDIEALGCSMDQDSA

Produktmerkmale: Length (AA): 464
Chromosomal location: 7p13

Reinheit: > 95 % by SDS-PAGE. Visualized by silver stain

Anwendungsinformationen

Applikationshinweise: Not tested so far.

Kommentare:

Cytokines & Growth Factors

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: The lyophilized CCM-2 is soluble in water and most aqueous buffers and should be reconstituted in water or PBS.

Buffer: PBS

Lagerung: 0 °C

Informationen zur Lagerung: The lyophilized human CCM2, though stable at room temperature, is best stored desiccated below 0 °C.

Antigendetails

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Andere Bezeichnung: CCM-2 (CCM2 Produkte)

Synonyme: C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein

Hintergrund: Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2). The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown. It was shown that the CCM1 gene product, KRIT1, interacts with the CCM2 gene product, malcavernin. Analogous to the established interactions of CCM1 and beta1 integrin with ICAP1, the CCM1/CCM2 association is dependent upon the phosphotyrosine binding (PTB) domain of CCM2. A familial CCM2 missense mutation abrogates the CCM1/CCM2 interaction, suggesting that loss of this interaction may be critical in CCM pathogenesis. CCM2 and ICAP1 bound to CCM1 via their respective PTB domains differentially influence the subcellular localization of CCM1. The data indicate that the genetic heterogeneity observed in familial CCM may reflect mutation of different molecular members of a coordinated signaling complex. The CCM-2 is fused to a N-terminal His-tag (6x His).
Synonyms: CCM-2, malcavernin, cerebral cavernous malformation 2, OSM, C7orf22, PP10187

Molekulargewicht: 51.0 kDa

NCBI Accession: NP_001025006, NM_001029835

UniProt: Q9BSQ5

Pathways: Cell-Cell Junction Organization