IL-2 Protein

Produktnummer ABIN1589645

Produktdetails

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLHYKDPAA NKARKEAELA AATAEQ

Produktmerkmale: Length (AA): 156
Chromosomal location: 4q26-q27
The ED50 as determined by the dose-dependent stimulation of proliferation of murine D10G4.1 cells is in the range of 0.1-0.5 ng/mL.

Reinheit: > 98 % by SDS-PAGE. Visualized by silver stain

Endotoxin-Niveau: < 0.1 ng per µg of IL-2

Anwendungsinformationen

Kommentare:

Cytokines & Growth Factors

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: The lyophilized IL-2 should be reconstituted in 50 mM acetic acid to a concentration not less than 100 μg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.

Buffer: 50 mM acetic acid

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: 0 °C

Informationen zur Lagerung: The lyophilized IL-2, though stable at room temperature, is best stored desiccated below 0 °C. Reconstituted IL-2 should be stored in workingaliquots at -20 °C.

Referenzen

Haustein, Ramer, Linnebacher, Manda, Hinz: "Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1." in: Biochemical pharmacology, Vol. 92, Issue 2, pp. 312-25, (2014) (PubMed).

Antigendetails

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Andere Bezeichnung: IL-2 (IL2 Produkte)

Synonyme: IL2 Protein, IL-2 Protein, il2 Protein, TCGF Protein, lymphokine Protein, Il-2 Protein, POIL2 Protein, interleukin 2 Protein, interleukin-15 Protein, IL2 Protein, il2 Protein, LOC100303688 Protein, Il2 Protein

Hintergrund: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.
Synonyms: IL2, IL-2, TCGF, lymphokine

Molekulargewicht: 15.5 kDa

NCBI Accession: NP_000577, NM_000586

UniProt: P60568

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation