KIT Ligand (KITLG) (Active) Protein

Details zu Produkt Nr. ABIN1525806
Proteinname
  • Xkl-1
  • Xsl
  • Xsl-1
  • Xsl-2
  • steel
  • KITLG
  • SCF
  • kitl
  • kl-1
  • mgf
  • scf
  • FPH2
  • KL-1
  • Kitl
  • MGF
  • SF
  • SHEP7
  • Clo
  • Con
  • Gb
  • Kitlg
  • Mgf
  • SLF
  • Sl
  • blz
  • contrasted
  • 710-712
  • CSF
  • KITL
  • KIT ligand L homeolog
  • KIT ligand
  • kit ligand
  • kitlg.L
  • KITLG
  • kitlg
  • Kitl
  • Kitlg
Spezies
Human
72
46
23
4
3
2
2
2
2
1
1
1
Quelle
HEK-293 Cells
97
10
10
8
8
3
3
3
2
2
2
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Applikation
SDS-PAGE (SDS)
Optionen
Marke CellExp™
Produktmerkmale Molecule Information: 35 to 45 kDa, monomer, glycosylated
Reinheit > 95 % by SDS-PAGE
Endotoxin-Niveau < 1.0 EU per 1 μg of protein
Biological Activity Comment ED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Proteinname
Hintergrund Stem cell factor / KIT ligand (SCF) is a cytokine which binds CD117(c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases. SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E (burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid).

Alternative Names: Kit ligand Precursor, C-kit ligand, SCF, Mast cell growth factor, MGF, SF, KL-1, Kit l, DKFZp686F2250.
Molekulargewicht 35 to 45 kDa, monomer, glycosylated
Gen-ID 4254
UniProt P21583
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Kommentare

Human CellExp™ Recombinant Proteins provide tremendous benefits for scientists performing human cell based studies:
- They contain all the post-translational modifications (which affects the activity, function and half-life) seen in human proteins.
- They mimic native human proteins in terms of sub-unit assembly, folding, secretion and other processes.
- They show the same chemical and biological properties like stability, isoelectric point, solubility, binding affinities and biological activity.
- They are produced in serum-free medium; hence they exhibit minimal batch to batch variability and are pathogen free products.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitute in sterile PBS containing 0.1 % endotoxin-free recombinant human serum albumin.
Buffer Lyophilized in PBS.
Handhabung Centrifuge the vial prior to opening.
Lagerung -80 °C
Haltbarkeit 12 months
Bilder des Herstellers
Image no. 1 for KIT Ligand (KITLG) (Active) protein (ABIN1525806) KIT Ligand (KITLG) (Active) protein (Image 1)
Image no. 2 for KIT Ligand (KITLG) (Active) protein (ABIN1525806) KIT Ligand (KITLG) (Active) protein (Image 2)