LAG3 Protein (Fc Tag)

Produktnummer ABIN1344460

Produktdetails

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human, Maus

Quelle: CHO Cells

Aufreinigungstag / Konjugat: Dieses LAG3 Protein ist gelabelt mit Fc Tag.

Applikation: SDS-PAGE (SDS), Flow Cytometry (FACS)

Spezifität: Binds to human and mouse MHC class II.

Kreuzreaktivität: Human, Maus

Produktmerkmale: The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labeled antibodies to IgG2a. Uni-Prot link Q61790: LAG-3 (mouse) http://www.uniprot.org/uniprot/Q61790Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS.

Lagerung: -20 °C

Informationen zur Lagerung: Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Referenzen

Cappello, Triebel, Iezzi, Caorsi, Quaglino, Lollini, Amici, Di Carlo, Musiani, Giovarelli, Forni: "LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice." in: Cancer research, Vol. 63, Issue 10, pp. 2518-25, (2003) (PubMed).

Antigendetails

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Andere Bezeichnung: LAG-3 (LAG3 Produkte)

Synonyme: CD223 Protein, LAG-3 Protein, Ly66 Protein, lymphocyte activating 3 Protein, lymphocyte-activation gene 3 Protein, LAG3 Protein, Lag3 Protein

Hintergrund: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Molekulargewicht: ~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)

UniProt: Q61790

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints