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IGFL3 Protein (AA 25-140) (DYKDDDDK Tag)

IGFL3 Spezies: Maus Wirt: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS
Produktnummer ABIN1344381
  • Target Alle IGFL3 Produkte
    IGFL3 (IGF-Like Family Member 3 (IGFL3))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 25-140
    Spezies
    • 2
    • 1
    Maus
    Quelle
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses IGFL3 Protein ist gelabelt mit DYKDDDDK Tag.
    Applikation
    SDS-PAGE (SDS)
    Kreuzreaktivität
    Maus
    Produktmerkmale
    Mouse IGFL (aa 25-140) is fused at the N-terminus to a FLAG®-tag.
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.1EU/μg purified protein (LAL test, Lonza).
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute with 100 μL sterile water.
    Konzentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Haltbarkeit
    6 months
  • Lobito, Ramani, Tom, Bazan, Luis, Fairbrother, Ouyang, Gonzalez: "Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1." in: The Journal of biological chemistry, Vol. 286, Issue 21, pp. 18969-81, (2011) (PubMed).

  • Target
    IGFL3 (IGF-Like Family Member 3 (IGFL3))
    Andere Bezeichnung
    IGFL (IGFL3 Produkte)
    Synonyme
    UNQ483 Protein, Gm580 Protein, Igfl Protein, Rprc483 Protein, Ceacam12 Protein, IGF like family member 3 Protein, IGF-like family member 3 Protein, IGFL3 Protein, Igfl3 Protein
    Hintergrund
    Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
    Molekulargewicht
    ~12kDa (SDS-PAGE)
    UniProt
    Q6B9Z0
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