HES1 Protein (AA 2-280) (His tag)

Produktnummer ABIN1344336

Produktdetails

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-280

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HES1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Human

Produktmerkmale: Human HES1 (aa 2-280) is fused at the N-terminus to a His-tag.

Reinheit: >90 % (SDS-PAGE)

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 3 months

Antigendetails

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: HES1 (HES1 Produkte)

Synonyme: HES-1 Protein, HHL Protein, HRY Protein, bHLHb39 Protein, Hry Protein, HAIRY1 Protein, c-hairy1A Protein, Xhairy1 Protein, hairy1 Protein, hes1 Protein, Xhairy-1 Protein, Xlh1 Protein, hes family bHLH transcription factor 1 Protein, hairy and enhancer of split 1 (Drosophila) Protein, hes family bHLH transcription factor 4 Protein, hes family bHLH transcription factor 1 S homeolog Protein, hes family bHLH transcription factor 1 L homeolog Protein, HES1 Protein, Hes1 Protein, HES4 Protein, hes1.S Protein, hes1.L Protein

Hintergrund: BHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.

Molekulargewicht: ~35kDa (SDS-PAGE)

UniProt: Q14469

Pathways: DNA Reparatur