Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

BAFF Protein (AA 127-309, Soluble) (DYKDDDDK Tag)

TNFSF13B Spezies: Human, Maus Wirt: HEK-293 Cells Recombinant >90 % (SDS-PAGE) SDS
Produktnummer ABIN1344293
  • Target Alle BAFF (TNFSF13B) Proteine anzeigen
    BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Soluble, AA 127-309
    Spezies
    • 36
    • 14
    • 3
    • 2
    • 2
    Human, Maus
    Quelle
    • 20
    • 19
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses BAFF Protein ist gelabelt mit DYKDDDDK Tag.
    Applikation
    SDS-PAGE (SDS)
    Spezifität
    Binds to human and mouse BAFF-R, TACI and BCMA.
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Mouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG®-tag.
    Reinheit
    >90 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product TNFSF13B Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute with 100 μL sterile water.
    Konzentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Haltbarkeit
    6 months
  • Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).

  • Target
    BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
    Andere Bezeichnung
    BAFF (TNFSF13B Produkte)
    Synonyme
    BAFF Protein, BLYS Protein, CD257 Protein, DTL Protein, TALL-1 Protein, TALL1 Protein, THANK Protein, TNFSF20 Protein, ZTNF4 Protein, BAFF-R Protein, BAFFR Protein, BROMIX Protein, CD268 Protein, CVID4 Protein, prolixin Protein, TNFSF13B Protein, RGD1561519 Protein, RGD1560810 Protein, BLyS Protein, D8Ertd387e Protein, zTNF4 Protein, 2010006P15Rik Protein, Baffr Protein, Bcmd Protein, Bcmd-1 Protein, Bcmd1 Protein, Lvis22 Protein, zgc:172115 Protein, TNF superfamily member 13b Protein, TNF receptor superfamily member 13C Protein, tumor necrosis factor (ligand) superfamily, member 13b Protein, tumor necrosis factor receptor superfamily, member 13c Protein, tumor necrosis factor superfamily member 13b Protein, TNFSF13B Protein, TNFRSF13C Protein, Tnfsf13b Protein, Tnfrsf13c Protein, tnfsf13b Protein
    Hintergrund
    BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.
    Molekulargewicht
    ~26kDa (SDS-PAGE)
    UniProt
    Q9WU72
    Pathways
    NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response
Sie sind hier:
Kundenservice