PSMB8 Protein (His tag)

Produktnummer ABIN1098710

Produktdetails

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PSMB8 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Reinheit: > 85 % by SDS - PAGE

Anwendungsinformationen

Kommentare:

Synonyms: proteasome (prosome, macropain) subunit, beta type, 8, D6S216, D6S216E, LMP7, MGC1491, PSMB5i

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea, 10% glycerol

Lagerung: 4 °C

Informationen zur Lagerung: Avoid repeated freezing and thawing cycles.

Antigendetails

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Andere Bezeichnung: PSMB8 (PSMB8 Produkte)

Synonyme: ALDD Protein, D6S216 Protein, D6S216E Protein, JMP Protein, LMP7 Protein, NKJO Protein, PSMB5i Protein, RING10 Protein, ATP6V0D2 Protein, lmp7 Protein, prosome Protein, macropain Protein, Lmp-7 Protein, Lmp7 Protein, Ring10 Protein, proteasome subunit beta 8 Protein, proteasome subunit beta 8A Protein, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Protein, PSMB8 Protein, psmb8a Protein, Psmb8 Protein

Hintergrund: PSMB8, also known as LMP7, belongs to the peptidase T1B family. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB8 is located in the class II region of the MHC (major histocompatibility complex). Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. This protein acts as a major component of interferon gamma-induced sensitivity. It plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. Recombinant human PSMB8 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 25.4 kDa (229aa)

NCBI Accession: NP_683720

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA