ZBTB17 Protein (AA 1-188) (His tag)

Produktnummer ABIN1097149

Produktdetails

Target: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-188

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ZBTB17 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human ZBTB17/Miz-1 (N-6His)

Sequenz: MGSSHHHHHH SSGLVPRGSH MDFPQHSQHV LEQLNQQRQL GLLCDCTFVV DGVHFKAHKA VLAACSEYFK MLFVDQKDVV HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVATFLQ MQDIITACHA LKSLAEPATS PGGNAEALAT EGGDKRAKEE KVATSTLSRL EQAGRSTPIG PSRDLKEERG GQAQSAASGA EQTEKADA

Produktmerkmale: Recombinant Human Zinc Finger and BTB Domain-Containing Protein 17/ZBTB17 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ala188) of Human ZBTB17 fused with a His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.25.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Andere Bezeichnung: Miz-1/ZBTB17 (ZBTB17 Produkte)

Synonyme: MIZ-1 Protein, ZNF151 Protein, ZNF60 Protein, pHZ-67 Protein, AA589413 Protein, Lp-1 Protein, Miz1 Protein, Zfp100 Protein, mZ13 Protein, Miz-1 Protein, zbtb17 Protein, zinc finger and BTB domain containing 17 Protein, zinc finger and BTB domain containing 17 S homeolog Protein, ZBTB17 Protein, Zbtb17 Protein, zbtb17.S Protein

Sub Type: Fusionprotein

Hintergrund: Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific genes, it has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. ZBTB17 may has growth arrest activity, probably through inhibition of cell cycle progression. ZBTB17 required for early embryonic development during gastrulation. ZBTB17 induces cell arrest at G1, an effect mediated by its activation of the gene coding for P15INK4b. This effect is blocked by Myc, which displaces transcriptional coactivators bound to ZBTB17. Although the downregulation of ZBTB17 may contribute to Myc-induced cell transformation, the de-activation of ZBTB17 is absolutely essential for Myc-induced apoptosis.
Alternative Names: Zinc Finger and BTB Domain-Containing Protein 17, Myc-Interacting Zinc Finger Protein 1, Miz-1, Zinc Finger Protein 151, Zinc Finger Protein 60, ZBTB17, MIZ1, ZNF151, ZNF60

Molekulargewicht: 22.33 kDa

UniProt: Q13105

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, ER-Nucleus Signaling