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MICA Protein (AA 24-308) (His tag)

MICA Spezies: Human Wirt: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1097146
  • Target Alle MICA Proteine anzeigen
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 24-308
    Spezies
    • 22
    • 1
    Human
    Quelle
    • 12
    • 5
    • 3
    • 2
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses MICA Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-6His)
    Sequenz
    EPHSLRYNLT VLSWDGSVQS GFLTEVHLDG QPFLRCDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETEEWTMP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLKSGVVLRR TVPPMVNVTR SEASEGNITV TCRASGFYPW NITLSWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC QGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHWQVDHHH HHH
    Produktmerkmale

    Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-6His)

    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product MICA Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Andere Bezeichnung
    MHC Class I Polypeptide-Related Sequence A/MICA (MICA Produkte)
    Synonyme
    MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
    Hintergrund
    Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Glu24-Gln308) of Human MICA fused with a polyhistidine tag at the C-terminus.
    MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical MHC class I molecules, MICA does not form a heterodimer with β-2-microglobulin. MICA shares 85 % AA identity with a closely related protein, MICB. MICA acts as a stress-induced self-antigen that is recognized by NK cells, NKT cells, and most of the subtypes of T cells. As a Ligand for the KLRK1/NKG2D receptor, MICA binds to KLRK1 leads to cell lysis. MICA functions as an antigen for γ δ T cells and is frequently expressed in epithelial tumors. MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients. Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
    Molekulargewicht
    33.87 kDa
    UniProt
    Q29983
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis
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