LAMP2 Protein (AA 29-375) (His tag)

Produktnummer ABIN1097059

Produktdetails

Target: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 29-375

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses LAMP2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human LAMP2/CD107b (C-6His)

Sequenz: LELNLTDSEN ATCLYAKWQM NFTVRYETTN KTYKTVTISD HGTVTYNGSI CGDDQNGPKI AVQFGPGFSW IANFTKAAST YSIDSVSFSY NTGDNTTFPD AEDKGILTVD ELLAIRIPLN DLFRCNSLST LEKNDVVQHY WDVLVQAFVQ NGTVSTNEFL CDKDKTSTVA PTIHTTVPSP TTTPTPKEKP EAGTYSVNNG NDTCLLATMG LQLNITQDKV ASVININPNT THSTGSCRSH TALLRLNSST IKYLDFVFAV KNENRFYLKE VNISMYLVNG SVFSIANNNL SYWDAPLGSS YMCNKEQTVS VSGAFQINTF DLRVQPFNVT QGKYSTAQEC SLDDDTIVDH HHHHH

Produktmerkmale: Recombinant Human Lysosome-Associated Membrane Glycoprotein 2/LAMP2 produced by transfected human cells is a secreted protein with sequence (Leu29-Ile375) of Human LAMP2 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Andere Bezeichnung: lamp2 (LAMP2 Produkte)

Synonyme: CD107b Protein, LAMP-2 Protein, LAMPB Protein, LGP110 Protein, Lamp-2 Protein, Lamp-2a Protein, Lamp-2b Protein, Lamp-2c Protein, Mac3 Protein, cd107b Protein, lamp-2 Protein, lampb Protein, LAMP2 Protein, lamp2 Protein, DKFZp459J126 Protein, LGP-B Protein, sb:cb587 Protein, wu:fb14a06 Protein, zgc:103532 Protein, lysosomal associated membrane protein 2 Protein, lysosomal-associated membrane protein 2 Protein, lysosomal-associated membrane protein 2 S homeolog Protein, lysosomal membrane glycoprotein 2 Protein, LAMP2 Protein, Lamp2 Protein, lamp2.S Protein, lamp2 Protein

Sub Type: Fusionprotein

Hintergrund: Lysosomal Associated Membrane Protein 2 (LAMP2) is a major component of lysosomal membranes. LAMP2 is a transmembrane glycoprotein about 110kDa. Mature human LAMP2 consists of a 347 amino acid (aa) intralumenal domain, a 24 aa transmembrane segment, and a 35 aa cytoplasmic tail . The lumenal domain is organized into two heavily N-glycosylated regions. Alternate splicing generates a human LAMP2 isoform (LAMP2B) with a substituted juxtamembrane lumenal region, cytoplasmic tail and transmenmbrane segment.LAMP2 itself can cleavage lysosomal luminal domain and degradation lysosomal. In the help of chaperone HSC73,LAMP2 mediates the lysosomal uptake in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles.
Alternative Names: Lysosome-Associated Membrane Glycoprotein 2, LAMP-2, Lysosome-Associated Membrane Protein 2, CD107 Antigen-Like Family Member B, CD107b, LAMP2

Molekulargewicht: 33.94 kDa

UniProt: P13473

Pathways: Autophagie