CD46 Protein (CD46) (AA 35-328) (His tag)

Produktnummer ABIN1096326

Produktdetails

Target: CD46

Protein-Typ: Recombinant

Proteineigenschaft: AA 35-328

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses CD46 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CD46/MCP (C-6His)

Sequenz: CEEPPTFEAM ELIGKPKPYY EIGERVDYKC KKGYFYIPPL ATHTICDRNH TWLPVSDDAC YRETCPYIRD PLNGQAVPAN GTYEFGYQMH FICNEGYYLI GEEILYCELK GSVAIWSGKP PICEKVLCTP PPKIKNGKHT FSEVEVFEYL DAVTYSCDPA PGPDPFSLIG ESTIYCGDNS VWSRAAPECK VVKCRFPVVE NGKQISGFGK KFYYKATVMF ECDKGFYLDG SDTIVCDSNS TWDPPVPKCL KVSTSSTTKS PASSASGPRP TYKPPVSNYP GYPKPEEGIL DSLDLDHHHH HH

Produktmerkmale: Recombinant Human CD46 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Cys35-Asp328) of Human CD46 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: CD46

Andere Bezeichnung: cd46 (CD46 Produkte)

Synonyme: AHUS2 Protein, MCP Protein, MIC10 Protein, TLX Protein, TRA2.10 Protein, Mcp Protein, CD46 Protein, CD46 molecule Protein, CD46 antigen, complement regulatory protein Protein, CD46 molecule, complement regulatory protein Protein, membrane cofactor protein-like Protein, CD46 Protein, Cd46 Protein, LOC100341359 Protein, LOC103789310 Protein

Sub Type: Fusionprotein

Hintergrund: CD46 is a type I membrane protein containing four Sushi domains. CD46 is expressed by all cells except erythrocytes. CD46 has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. CD46 acts as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria.
Alternative Names: Membrane Cofactor Protein, TLX, Trophoblast Leukocyte Common Antigen, CD46, MCP, MIC10

Molekulargewicht: 33.83 kDa

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization