Azurocidin Protein (AA 27-250) (His tag)

Produktnummer ABIN1096068

Produktdetails

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-250

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Azurocidin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Azurocidin/CAP37/HBP (C-6His)

Sequenz: IVGGRKARPR QFPFLASIQN QGRHFCGGAL IHARFVMTAA SCFQSQNPGV STVVLGAYDL RRRERQSRQT FSISSMSENG YDPQQNLNDL MLLQLDREAN LTSSVTILPL PLQNATVEAG TRCQVAGWGS QRSGGRLSRF PRFVNVTVTP EDQCRPNNVC TGVLTRRGGI CNGDGGTPLV CEGLAHGVAS FSLGPCGRGP DFFTRVALFR DWIDGVLNNP GPGPVDHHHH HH

Produktmerkmale: Recombinant Human Azurocidin produced by transfected human cells is a secreted protein with sequence (Ile27-Pro250) of Human AZU1 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, pH 7.5.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Andere Bezeichnung: cap37 (AZU1 Produkte)

Synonyme: AZAMP Protein, AZU Protein, CAP37 Protein, HBP Protein, HUMAZUR Protein, NAZC Protein, AZU1 Protein, Azurocidin Protein, pHBP Protein, azurocidin 1 Protein, azurocidin Protein, AZU1 Protein, CpipJ_CPIJ007384 Protein

Sub Type: Fusionprotein

Hintergrund: Azurocidin is an Azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, Neutrophil Elastase (NE), and Proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Human Azurocidin together with NE and PR3 are expressed coordinately and are packaged together into azurophil granules during neutrophil differentiation. Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator. Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.
Alternative Names: Azurocidin, Cationic Antimicrobial Protein CAP37, Heparin-Binding Protein, HBP, AZU1

Molekulargewicht: 25.24 kDa

UniProt: P20160