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APEX1 Protein (AA 2-318)

APEX1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1096032
  • Target Alle APEX1 Proteine anzeigen
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 2-318
    Spezies
    • 14
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 9
    • 7
    • 4
    • 2
    • 2
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Human Apurinic-Apyrimidinic Endonuclease 1/APE
    Sequenz
    MGPKRGKKGA VAEDGDELRT EPEAKKSKTA AKKNDKEAAG EGPALYEDPP DQKTSPSGKP ATLKICSWNV DGLRAWIKKK GLDWVKEEAP DILCLQETKC SENKLPAELQ ELPGLSHQYW SAPSDKEGYS GVGLLSRQCP LKVSYGIGEE EHDQEGRVIV AEFDSFVLVT AYVPNAGRGL VRLEYRQRWD EAFRKFLKGL ASRKPLVLCG DLNVAHEEID LRNPKGNKKN AGFTPQERQG FGELLQAVPL ADSFRHLYPN TPYAYTFWTY MMNARSKNVG WRLDYFLLSH SLLPALCDSK IRSKALGSDH CPITLYLAL
    Produktmerkmale
    Recombinant Human Apurinic-Apyrimidinic Endonuclease 1/APE1 is produced with our E. coli expression system. The target protein is expressed with sequence (Pro2-Leu318) of Human APE1.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product APEX1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50 % Glycerol, pH 7.4.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    Andere Bezeichnung
    APE1 (APEX1 Produkte)
    Synonyme
    apex1 Protein, MGC76280 Protein, MGC79645 Protein, MGC78928 Protein, APE Protein, APE1 Protein, APEN Protein, APEX Protein, APX Protein, HAP1 Protein, REF1 Protein, Apex Protein, REF-1 Protein, BAP1 Protein, apex1a Protein, hm:zehn1532 Protein, wu:fc13d11 Protein, zgc:66204 Protein, Ref-1 Protein, apurinic/apyrimidinic endodeoxyribonuclease 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog Protein, DNA-(apurinic or apyrimidinic site) lyase Protein, apurinic/apyrimidinic endonuclease 1 Protein, APEX1 Protein, apex1 Protein, apex1.L Protein, CNG03640 Protein, CNH01280 Protein, nth Protein, Spirs_4119 Protein, Palpr_0103 Protein, Apex1 Protein
    Hintergrund
    Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
    Alternative Names: DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1 REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
    Molekulargewicht
    35.62 kDa
    UniProt
    P27695
    Pathways
    DNA Reparatur, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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