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HNRNPD/AUF1 Protein (AA 18-355, partial) (GST tag)

HNRNPD Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA
Produktnummer ABIN1047165
  • Target Alle HNRNPD/AUF1 (HNRNPD) Proteine anzeigen
    HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 18-355, partial
    Spezies
    • 6
    • 1
    • 1
    Human
    Quelle
    • 4
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses HNRNPD/AUF1 Protein ist gelabelt mit GST tag.
    Applikation
    SDS-PAGE (SDS), ELISA
    Sequenz
    AVGGSAGEQE GAMVAATQGA AAAAGSGAGT GGGTASGGTE GGSAESEGAK IDASKNEEDE GHSNSSPRHS EAATAQREEW KMFIGGLSWD TTKKDLKDYF SKFGEVVDCT LKLDPITGRS RGFGFVLFKE SESVDKVMDQ KEHKLNGKVI DPKRAKAMKT KEPVKKIFVG GLSPDTPEEK IREYFGGFGE VESIELPMDN KTNKRRGFCF ITFKEEEPVK KIMEKKYHNV GLSKCEIKVA MSKEQYQQQQ QWGSRGGFAG RARGRGGDQQ SGYGKVSRRG GHQNSYKPY
    Produktmerkmale
    Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Ref.13 Ref.30
    Reinheit
    90 %
    Top Product
    Discover our top product HNRNPD Protein
  • Kommentare

    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS buffer, 20mM GSH
    Lagerung
    -20 °C
  • Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).

    Dempsey, Li, DePace, Bray-Ward, Maizels: "The human HNRPD locus maps to 4q21 and encodes a highly conserved protein." in: Genomics, Vol. 49, Issue 3, pp. 378-84, (1998) (PubMed).

    Kajita, Nakayama, Aizawa, Ishikawa: "The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family." in: The Journal of biological chemistry, Vol. 270, Issue 38, pp. 22167-75, (1995) (PubMed).

  • Target
    HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))
    Andere Bezeichnung
    Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD Produkte)
    Synonyme
    AUF1 Protein, AUF1A Protein, HNRPD Protein, P37 Protein, hnRNPD0 Protein, Auf1 Protein, Hnrnpd Protein, HNRNPD Protein, p37 Protein, auf1a Protein, hnrpd Protein, hnrnpd0 Protein, C230004L04 Protein, Hnrpd Protein, wu:fa28b06 Protein, zgc:162951 Protein, heterogeneous nuclear ribonucleoprotein D Protein, heterogeneous nuclear ribonucleoprotein D L homeolog Protein, HNRNPD Protein, Hnrnpd Protein, hnrnpd Protein, hnrnpd.L Protein
    Hintergrund
    Synonyms: AU-rich element RNA-binding protein 1
    Molekulargewicht
    58.6 kD
    UniProt
    Q14103
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