Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)

Details zu Produkt Nr. ABIN1046691, Anbieter: Anmelden zum Anzeigen
Proteinname
  • Rantes
  • Scya5
  • D17S136E
  • RANTES
  • SCYA5
  • SIS-delta
  • SISd
  • TCP228
  • eoCP
  • MuRantes
  • C-C motif chemokine 5-like
  • C-C motif chemokine ligand 5
  • chemokine (C-C motif) ligand 5
  • LOC100230935
  • CCL5
  • Ccl5
Proteineigenschaft
AA 24-91, full length
30
2
2
2
1
1
1
1
1
Spezies
Human
56
19
11
3
3
2
2
2
2
1
1
1
Quelle
Escherichia coli (E. coli)
83
9
1
1
1
1
1
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses CCL5 Protein ist gelabelt mit His tag.
Applikation
ELISA
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Sequenz SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
Produktmerkmale Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Reinheit 90 %
Hintergrund Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. Ref.3 Ref.8 Ref.10 Ref.11 Ref.12
Molekulargewicht 11.9 kD
UniProt P13501
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration
Kommentare

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Konzentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handhabung Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Bilder des Herstellers
SDS-PAGE (SDS) image for Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag) (ABIN1046691) Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)
Allgemeine Veröffentlichungen Capoulade-Métay, Ayouba, Kfutwah, Lole, Pêtres, Dudoit, Deterre, Menu, Barré-Sinoussi, Debré, Theodorou: "A natural CCL5/RANTES variant antagonist for CCR1 and CCR3." in: Immunogenetics, Vol. 58, Issue 7, pp. 533-41, 2006 (PubMed).

Schall, Jongstra, Dyer, Jorgensen, Clayberger, Davis, Krensky: "A human T cell-specific molecule is a member of a new gene family." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 3, pp. 1018-25, 1988 (PubMed).

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