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Development of a pipeline for automated, high-throughput analysis of PSPC1 paraspeckle protein isoforms reveals specific roles for KPNA2, KPNA4 and KPNA6 proteins.
Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.
Our results suggest a potential role of Hsa-miR-567 as a novel prognostic biomarker for BC and as regulator of KPNA4.
These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4.
Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b.
Karyopherin alpha 3 and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.
miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
upon DNA damage transport adaptor importin-alpha4 imports XPA into the nucleus in an ATR-dependent manner.
Importin alpha3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function.
Impalpha3 is an HIV integrase-interacting cofactor and is required for efficient HIV-1 nuclear import and replication.
The papillomavirus E2 proteins preferentially interacted with alpha importins 3 and 5, and showed very weak or no interaction with the other three widely expressed alpha importins (alpha1, alpha 4, and alpha 7).
stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin-alpha3 and rapid import
Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in cells overexpressing PHB.
Our results indicate that the nuclear import of RHA is mediated by the importin-alpha3/importin-beta-dependent pathway and suggest that the specificity for importin may regulate the functions of cargo proteins.
Daxx interacts selectively with importin alpha3 through its NLS1 and NLS2 sequences. Conversely, importin alpha3 utilizes two NLS-binding sites for Daxx interaction, suggesting that it mediates nuclear import of Daxx.
MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [MOS6]
Loss of importin alpha 4 is associated with oxidative stress.
IMPalpha4 overexpression induced a significant decrease in Oct3/4 protein levels compared to control transfections. IMPalpha4 protein showed a unique and striking shift in subcellular localization from the nucleus to the cytoplasm during differentiation.
Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in colonic mucosa cells of transgenic mice overexpressing human prohibitin.
In postnatal testes, importin alpha3 and alpha4 in spermatocytes, spermatids, and Sertoli cells display cytoplasmic and nuclear localization, respectively.
These results suggest that the bovine adenovirus-3 52K protein contains a bipartite nuclear localization signal, which preferentially utilize an importin alpha3 nuclear import receptor-mediated pathway to transport the 52K protein to the nucleus.
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
importin alpha Q1
, importin subunit alpha-3
, importin subunit alpha-4
, karyopherin subunit alpha-4
, importin alpha 3
, karyopherin alpha 4 (importin alpha 3)
, karyopherin (importin) alpha 4
, predicted role in nuclear import