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Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 (zeige PDCD1 Proteine) or its ligand (PD-L1 (zeige CD274 Proteine)) together with immune stimulatory agonist Abs like anti-OX40 are being tested in the clinic to achieve improved antitumor effects
High Fat Diet-induced obese mice exhibit increased OX40 expression in adipose tissues and splenic T cells.
These data support the hypothesis that the Ox40/Ox40L (zeige TNFSF4 Proteine) pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1 mice and emphasize the potential clinical value of targeting this pathway in human lupus.
OX40 is a death receptor for invariant natural killer T cells and is implicated in pyroptotic cell death.
this study shows that OX40 links a costimulatory receptor to a repressive chromatin remodeling pathway, and that that OX40 stimulation inhibits IL-17 (zeige IL17A Proteine) and reduces experimental autoimmune encephalomyelitis
IFNalphaR1 signaling promoted CXCL9 (zeige CXCL9 Proteine) and CXCL10 (zeige CXCL10 Proteine) synthesis, suggesting that these chemokines might be involved in the LPS (zeige TLR4 Proteine) and CD134 costimulation response.
OX40 and ICOS (zeige ICOS Proteine) act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection
OX40 regulates cardiac remodelling via the modulation of CD4 (zeige CD4 Proteine)(+) T-lymphocytes.
bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4 (zeige CD4 Proteine)+ T cells to Th2 cells by ligation of OX40L (zeige TNFSF4 Proteine) and OX40 between BMMC-exosomes and CD4 (zeige CD4 Proteine)+ T cells and represents a novel mechanism of cell-to-cell communication
Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes.
Increased OX40 expression is associated with gastric cancer.
this study demonstrates that cSCCs contain an abundance of Tregs which can suppress tumoral effector T cell function and that activation of the costimulatory receptor OX40 enhances tumoral T cell responses.
OX40 expression on T cells was positively associated with obesity in humans.
Metabolically active CD4 (zeige CD4 Proteine)+ T cells expressing Glut1 (zeige SLC2A1 Proteine) and OX40 preferentially harbor HIV during in vitro infection.
OX40 and OX40L (zeige TNFSF4 Proteine) formed a functional complex, which may facilitate signal transduction from OX40L (zeige TNFSF4 Proteine) to OX40 and contribute to the pathogenesis of Grave's disease.
this study investigated whether CD134 is preferentially expressed on CD4 (zeige CD4 Proteine) T cells in drug-induced hypersensitivity syndrome .
blocking of both OX-40L (zeige TNFSF4 Proteine) and 4-1BBL (zeige TNFSF9 Proteine) reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.
Low OX40 expression is associated with colorectal cancer.
OX40 and its ligand are co stimulators for T lymphocytes.
These studies provide the first direct evidence that ligation of tumour necrosis factor (zeige TNF Proteine) superfamily members and their cognate receptors is important for the control of viral lytic replication.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
tumor necrosis factor receptor superfamily, member 4
, tumor necrosis factor receptor superfamily member 4
, OX40 antigen
, OX40L receptor
, tax-transcriptionally activated glycoprotein 1
, ACT35 antigen
, ATC35 antigen
, CD134 antigen
, OX40 cell surface antigen
, OX40 homologue
, TAX transcriptionally-activated glycoprotein 1 receptor
, lymphoid activation antigene ACT35
, tax-transcriptionally activated glycoprotein 1 receptor
, MRC OX40
, Tax-transcriptionally activated glycoprotein 1
, tumor necrosis factor (ligand) superfamily member 4
, tumor necrosis factor superfamily, member 4