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Data suggest that marginal zone B and B1 cell specific protein (MZB1) may be a potential therapeutic target in excessive antibody-secreting cells in systemic lupus erythematosus (SLE).
expression was positively correlated with a high accumulation of CD8(+) tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy
Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection.
High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.
miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1.
results suggested that MGC29506 has the potential of functioning as a novel suppressor gene in gastric cancer
methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis
Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer.
MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506]
Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes.
MZB1 seems to act as a substrate-specific cochaperone of GRP94 that enables proper biosynthesis of microHCs under conditions of ER stress.
In a mouse model of asthma 2010001M09Rik (Mzb1) was unaltered 24 hours after allergen exposure, however, by 72 hours a marked increase in 2010001M09Rik mRNA was detected in lung tissue from disease-susceptible C57BL/6 and BALB/c mice.
Mzb1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation.
Data suggest that pERp1 is either a unique type of oxidoreductase or a previously unidentified class of molecular chaperone that is dedicated to enhancing the oxidative folding of Ig precursors.
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).
Proapoptotic caspase adapter protein
, marginal zone B- and B1-cell-specific protein
, plasma cell-induced ER protein 1
, plasma cell-induced resident ER protein
, plasma cell-induced resident endoplasmic reticulum protein
, caspase-2 binding protein
, mesenteric estrogen-dependent adipose 7
, mesenteric oestrogen-dependent adipose gene- 7
, proapoptotic caspase adapter protein
, proapoptotic caspase adaptor protein