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In this study, ChIP/chip datasets are analyzed using the corresponding PWMs for the well-studied TFs; CAUDAL, HUNCHBACK, KNIRPS and KRUPPEL, to determine the distribution of predicted binding sites. All four TFs are critical regulators of gene expression along the anterio-posterior axis in early Drosophila development
Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz (zeige NR5A1 ELISA Kits)) Caudal target gene.
Bicoid acts through a 63 nt response element in the caudal 3' untranslated region that includes a single miR (zeige MYLIP ELISA Kits)-2 target site. Four predicted Bicoid splice isoforms are capable of caudal repression; all require the microRNA target for repression.
Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region.
Bicoid recruits Bin3 to the caudal 3' UTR (zeige UTS2R ELISA Kits).
Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.
The caudal homeodomain protein activates Drosophila E2F (zeige E2F2 ELISA Kits) gene expression.
Transcriptional activation of the Drosophila caudal homeobox gene by the DRE-binding factor (DREF).
In this study, we have identified the binding sites for bHLH-PAS (zeige PASK ELISA Kits) proteins, referred to as CNS midline element (CME), in the 5'-flanking region of the Drosophila caudal gene.
study shows that the intestinal homeobox (zeige PRRX1 ELISA Kits) gene Caudal regulates the commensal-gut (zeige GUSB ELISA Kits) mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide (zeige cAMP ELISA Kits) genes
Dff40 (zeige DFFB ELISA Kits) expression is upregulated in atherosclerotic plaque. Dff40 (zeige DFFB ELISA Kits) deficiency inhibited high-fat diet-induced atherosclerosis, as evidenced by decreased atherosclerotic plaques, inhibited inflammatory response, and macrophage apoptosis, as well as enhanced stability of plaques.
CAD functions as a necessary modulator of the hypertrophic response by regulating the mitogen-activated protein kinase (zeige MAPK1 ELISA Kits)-extracellular signal-regulated kinase 1/2 (zeige MAPK3 ELISA Kits) signaling pathway in the heart.
the highest order of chromatin compaction observed in the later steps of caspase (zeige CASP3 ELISA Kits)-dependent apoptosis relies on DFF40/CAD (zeige DFFB ELISA Kits)-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks
results show that caspase 3 (zeige CASP3 ELISA Kits)/CAD promotes cell differentiation by directly modifying the DNA/nuclear microenvironment, which enhances the expression of critical regulatory genes
Co-transfection of mouse DFF45 (zeige DFFA ELISA Kits)(-/-) fibroblasts with plasmids encoding human DFF40 (zeige DFFB ELISA Kits) and DFF45 (zeige DFFA ELISA Kits) reversed the apoptosis resistance normally observed in these cells
The thymus of DNase II(-/-)CAD(-/-) embryos contained many foci carrying undigested DNA and the cellularity was severely reduced due to a block in T cell development.
Interactions identified here between mouse liver histone H1 (zeige H1F0 ELISA Kits) carboxyl-terminal domain and DFF40/CAD (zeige DFFB ELISA Kits) target and activate linker DNA cleavage during the terminal stages of apoptosis.
The results suggest that CAD protein may be preferentially degraded by the ubiquitin-proteasome system in the absence of its inhibitor (ICAD (zeige DFFA ELISA Kits)) to maintain protein quality control.
A los of caspase-activated DNASE (zeige DFFB ELISA Kits) enhances tumorigenesis induced by a chemical carcinogen in a model of skin carcinogenesis in mice.
These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch/Vegf signaling during angiogenesis.
an essential role for CAD in facilitating proliferation and differentiation events in a tissue-specific manner
This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures.
Changes in glycosylation in caused by mutations in CAD.
These results establish CAD as a downstream effector of Rheb (zeige RHEB ELISA Kits) and suggest a possible role of Rheb (zeige RHEB ELISA Kits) in regulating de novo pyrimidine nucleotide synthesis
Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
The results obtained indicate that mLST8 (zeige MLST8 ELISA Kits) bridges between CAD and mTOR (zeige FRAP1 ELISA Kits), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (zeige FRAP1 ELISA Kits) pathway through the association with mLST8 (zeige MLST8 ELISA Kits)
preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD
findings show that in prostate tumor cells, CAD fosters androgen receptor (zeige AR ELISA Kits) translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse
the cad gene is regulated by a nonclassical ERalpha (zeige ESR1 ELISA Kits)/Sp1 (zeige PSG1 ELISA Kits)-mediated pathway.
Data show that PRMT5 can be found in association with hSWI/SNF complexes and is involved in regulating the expression of carbamoyl-phosphate synthase-aspartate carbamoyltransferase-dihydroorotase.
the nuclear import of CAD appears to promote optimal cell growth
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
, CAD protein
, carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
, CAD protein-like
, CAD trifunctional protein
, multifunctional protein CAD
, carbamyl phosphatate synthetase 2
, CAD protein carbamylphosphate synthetase domain
, dihydrorotate synthase
, DNA fragmentation factor subunit beta
, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
, DNA fragmentation factor 40 kDa subunit
, DNA fragmentation factor, 40 kD, beta subunit
, DNase inhibited by DNA fragmentation factor
, caspase-activated DNase
, caspase-activated deoxyribonuclease