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Mouse (Murine) Polyclonal CAD Primary Antibody für ELISA, ICC - ABIN4286809
Hara, Miyake, Arakawa, Kamidono, Hara: Over expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo. in The Journal of urology 2001
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Human Polyclonal CAD Primary Antibody für ICC, IF - ABIN253268
Morin, Fritsch, Mathieu, Gilbert, Guarmit, Firlej, Gallou-Kabani, Vieillefond, Delongchamps, Cabon: Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
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Guinea Pig Polyclonal CAD Primary Antibody für ELISA, IHC - ABIN1584131
Zhdanov, Fahmi, Wang, Apostolov, Sokolov, Javadov, Basnakian: Regulation of Apoptotic Endonucleases by EndoG. in DNA and cell biology 2015
CAD dihydroorotase and aspartate transcarbamoylase domains self-assembles into dimers and trimers.
Detection of the CAD-ALK gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK kinase mutations that emerged during treatment with the ALK inhibitor entrectinib
This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures.
Changes in glycosylation in caused by mutations in CAD.
These results establish CAD as a downstream effector of Rheb (zeige RHEB Antikörper) and suggest a possible role of Rheb (zeige RHEB Antikörper) in regulating de novo pyrimidine nucleotide synthesis
Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
The results obtained indicate that mLST8 (zeige MLST8 Antikörper) bridges between CAD and mTOR (zeige FRAP1 Antikörper), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (zeige FRAP1 Antikörper) pathway through the association with mLST8 (zeige MLST8 Antikörper)
preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD
findings show that in prostate tumor cells, CAD fosters androgen receptor (zeige AR Antikörper) translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse
the cad gene is regulated by a nonclassical ERalpha (zeige ESR1 Antikörper)/Sp1 (zeige PSG1 Antikörper)-mediated pathway.
CAD functions as a necessary modulator of the hypertrophic response by regulating the mitogen-activated protein kinase (zeige MAPK1 Antikörper)-extracellular signal-regulated kinase 1/2 (zeige MAPK3 Antikörper) signaling pathway in the heart.
These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch (zeige NOTCH1 Antikörper)/Vegf (zeige VEGFA Antikörper) signaling during angiogenesis.
an essential role for CAD in facilitating proliferation and differentiation events in a tissue-specific manner
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
, CAD trifunctional protein
, multifunctional protein CAD
, carbamyl phosphatate synthetase 2
, carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
, CAD protein-like
, CAD protein carbamylphosphate synthetase domain
, dihydrorotate synthase