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Xeya3 is a key factor for the formation and size control of brain and eyes in vertebrates.
Data demonstrate that Eya3 and its partner Six1 (zeige SIX1 Proteine) synergistically activate TSHbeta (zeige TSHB Proteine) expression and that this activation is further enhanced by Tef (zeige TEF Proteine) and Hlf (zeige HLF Proteine).
The phosphatase function of Eya switches the function of Six1 (zeige SIX1 Proteine)-Dach (zeige DACH1 Proteine) from repression to activation, causing transcriptional activation through recruitment of co-activators
Experiments performed in cultured Drosophila cells and in vitro indicate that Eyes absent has intrinsic protein tyrosine phosphatase (zeige ACP1 Proteine) activity and can autocatalytically dephosphorylate itself
Ski (zeige SKI Proteine) is necessary for muscle terminal differentiation and that it exerts this role, at least in part, through its association with Six1 (zeige SIX1 Proteine) and Eya3 to regulate the Myog (zeige MYOG Proteine) transcription
There was no obvious defect in the eyes, ears and kidneys of Eya3 mutant mice. Homozygous mutants displayed decreased bone mineral content and shorter body length.
Study identifies Eya3 as a regulator of PP2A (zeige PPP2R4 Proteine), a major cellular Ser (zeige SIGLEC1 Proteine)/Thr (zeige TRH Proteine) phosphatase, and uncovers a mechanism of controlling the stability of a critical oncogene (zeige RAB1A Proteine), c-Myc (zeige MYC Proteine).
Benzbromarone metabolites and derivatives function as EYA3 inhibitory anti-angiogenic agents.
These studies identify EYA3 as a novel mediator of chemoresistance in Ewing sarcoma and define the molecular mechanisms of both EYA3 overexpression and of EYA3-mediated chemoresistance
EYA2 (zeige EYA2 Proteine) and EYA3 displayed specificity for Tyr (zeige TYR Proteine)-142 of H2A.X (zeige H2AFX Proteine)
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. A similar protein in mice acts as a transcriptional activator.
eyes absent homolog 3
, eyes absent 3
, eyes absent 3 homolog