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This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
eukaryotic translation elongation factor 1 epsilon 1
, eukaryotic translation elongation factor 1 epsilon-1
, ARS-interacting multifunctional protein 3
, aminoacyl tRNA synthetase complex-interacting multifunctional protein 3
, multisynthase complex auxiliary component p18
, p18 component of aminoacyl-tRNA synthetase complex
, elongation factor p18
, multisynthetase complex auxiliary component p18
, Elongation factor p18
, Multisynthase complex auxiliary component p18