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TRH rs13097335 may have a protective role toward the development of breast cancer.
Data indicate that decrease of cholesterol level impaired the functional coupling between the thyrotropin-releasing hormone receptor and the cognate G proteins.
TRH, LH-RH and substance P (zeige TAC1 Proteine) are not affected in Alzheimer disease and Down's syndrome.
Cpe (zeige CPE Proteine) mutations in mouse may affect processing of prothyrotropin releasing hormone into thyrotropin releasing hormone.
TRH inhibits melanin-concentrating hormone (MCH (zeige PMCH Proteine)) neurons by increasing synaptic inhibition from local GABA neurons.
This study introduces TRH as a novel, potent, selective, and evolutionarily highly conserved neuroendocrine factor controlling human pigmentation in situ.
Case Report: Isolated idiopathic central hypothyroidism in an adult, possibly caused by thyrotropin releasing hormone (TRH) deficiency.
Thus, human scalp hair follicles are both a source and a target of TRH, which operates as a potent hair-growth stimulator
TRH mRNA levels in "mute" thyrotropinomas: cause-effect or coincidence?
results show that that leptin (zeige LEP Proteine) can regulate trh gene expression via activation of intracellular signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) proteins in TRH neurons in the hypothalamus
Distribution of the mRNAs encoding proTRH and the three TRH receptors in the central nervous system and pituitary of X. laevis is described.
TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development.
co-regulation of the enzyme glutaminyl cyclase (zeige QPCT Proteine) and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (zeige APP Proteine) deposits
RXRA (zeige RXRA Proteine) and RXRB (zeige RXRB Proteine) display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone.
Reversal of hypothyroidism in female patient after treatment with thyrotropin releasing hormone.
Data suggest that expression of TRH is up-regulated by CREM (cAMP responsive element modulator (zeige CREM Proteine) protein) in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of CREM (zeige CREM Proteine) or CREB (cAMP responsive element binding protein (zeige CREB1 Proteine)).
Thyrotropin-releasing hormone altered the basal expression of the TSHbeta (zeige TSHB Proteine) gene and the responsiveness of the gene to thyroid hormone (zeige PTH Proteine).
Klf4 (zeige KLF4 Proteine) plays a key role in the maturation of TRH expression in hypothalamic neurons.
Data demonstrate that the distribution of hypophysiotropic TRH neurons in mice is vastly different from the pattern in rats, with a dominant occurrence of these neurosecretory cells in the compact part and adjacent regions at the mid-level of the PVN.
These demonstrations of PPARgamma (zeige PPARG Proteine) effects on hypothalamic Trh transcription in vivo consolidate the role of the TRH neuron as a central integrator of energy homeostasis.
study provides functional in vivo data showing that both thyroid hormone receptor (zeige THRA Proteine) beta1 and beta2 isoforms have specific roles in regulating thyrotropin releasing hormone transcription
This hormone is responsible for the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism.
, pro-thyrotropin-releasing hormone
, thyrotropin releasing hormone
, thyrotropin-releasing factor
, prepro-thyrotropin-releasing hormone
, thyrotropin-releasing hormone
, pro-thyrotropin-releasing hormone-B
, prothyroliberin type B
, pro-thyrotropin-releasing hormone-A
, prothyroliberin type A
, thyroliberin type A