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These data suggest that Schistosoma japonicum Sjp40 might inhibit hepatic stellate cell activation by promoting cellular senescence via SKP2/P27 (zeige PAK2 Proteine) signaling pathway.
human epidermal growth factor receptor (zeige EGFR Proteine) 2 (HER-2 (zeige ERBB2 Proteine)) levels, were correlated well with TSP50 (zeige PRSS50 Proteine)/p-Samd2 (zeige SARM1 Proteine)/3 and TSP50 (zeige PRSS50 Proteine)/p27 (zeige PAK2 Proteine) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (zeige PRSS50 Proteine)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
Furthermore, inhibition of COPS5 (zeige COPS5 Proteine) resulted in an elevation of Akt (zeige AKT1 Proteine) expression and sensitized SOC (zeige UBXN11 Proteine) cells to Akt (zeige AKT1 Proteine) inhibitor MK2206. Suppression of COPS5 (zeige COPS5 Proteine) and Akt (zeige AKT1 Proteine) offers a potential strategy for the treatment of SOC (zeige UBXN11 Proteine).
Loss of p27 (zeige PAK2 Proteine) associated with risk for endometrial carcinoma arising in the setting of obesity.
p53 (zeige TP53 Proteine) immunopositivity was more frequent in SCC (zeige CYP11A1 Proteine) (65%) than in VC (23%) (P=0.001). VC had lower p53 (zeige TP53 Proteine) as compared with well-differentiated SCC (zeige CYP11A1 Proteine) and SCC (zeige CYP11A1 Proteine) without lymph node metastasis. No significant difference was seen in pRb (zeige RB1 Proteine), p16, and p27 (zeige PAK2 Proteine) expression
The PSMD9 intronic SNPs rs74421874 (IVS3+nt460 G>A) and rs3825172 (IVS3+nt437 C>T) remain significantly associated with insomnia only when taking into account anxiety -and not depression- as covariate.
Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit (zeige PSMD14 Proteine) 9 (zeige ATP5G1 Proteine) (PSMD9), proteasome alpha type 7 (zeige PSMA7 Proteine) subunit (PSMA7 (zeige PSMA7 Proteine)) and PSMD13 (zeige PSMD13 Proteine) genes.
recurrence rate of p27 and/or PTEN-negative patients was higher than that of the positive ones,that should be followed up closely after treatment
The present study provided the first evidences that miR (zeige MLXIP Proteine)-1470 mediated lapatinib induced p27 (zeige PAK2 Proteine) upregulation by targeting c-jun (zeige JUN Proteine).
Staining intensities of cell cycle inhibitors p27 (zeige PAK2 Proteine) and p57 (zeige CDKN1C Proteine) significantly increased in all parts of preeclamptic placentas compared to control
These results therefore suggest that proteasomes, particularly p27 (zeige CDKN1B Proteine) subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene.
26S proteasome non-ATPase regulatory subunit 9
, 26S proteasome regulatory subunit p27
, homolog of rat Bridge 1
, proteasome 26S non-ATPase regulatory subunit 9
, transactivating protein Bridge-1
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
, proteasome 26S non-ATPase subunit 9
, PDZ domain-containing protein