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Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.
Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.
In the present study, the protein inhibitor of activated STAT (zeige STAT1 Proteine) Y (PIASy (zeige PIAS4 Proteine)) was identified as a novel Isl1-interacting protein. Furthermore, PIASy (zeige PIAS4 Proteine) and Isl1 upregulate insulin (zeige INS Proteine) gene expression and insulin (zeige INS Proteine) secretion in a dose-dependent manner by activating the insulin (zeige INS Proteine) promoter.
Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1 (zeige CCNB1 Proteine)), cyclin B2 (CCNB2 (zeige CCNB2 Proteine)) and c-myc (c-MYC (zeige MYC Proteine)) genes by binding to the conserved binding sites on their promoters or enhancers.
results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations.
ISL-1 is widely expressed in Olfactory neuroblastoma (zeige ARHGEF16 Proteine) tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis
Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway showed increased gene expression of ISL1, OCT4 (zeige POU5F1 Proteine), KDR (zeige KDR Proteine) and NKX2.5 (zeige NKX2-5 Proteine).
In bladder exstrophy there is a clear correlation with the a mutation of the chromosome 5 ISL1 (5q11.1) gene.
SSBP3 (zeige SSBP3 Proteine) Interacts With Islet-1 and Ldb1 (zeige LDB1 Proteine) to Impact Pancreatic beta-Cell Target Genes
Concurrent ISL1/HOXA9 (zeige HOXA9 Proteine) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality
Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.
The present study identified the first genome-wide significant locus for classic bladder exstrophy at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.
ISL1 plays a central role in proper patterning of stem cell-derived enamel in the incisor and indicate that this factor is an important upstream regulator of signaling pathways during tooth development and renewal.
Both ISL1-LHX3 and ISL1-LHX4 bound to the Slit2 enhancer.
results support a model in which Gata6 (zeige GATA6 Proteine) contributes to repression of Isl1 expression in the anterior of nascent hindlimb buds.
The results demonstrated that Islet1 upregulated expression of general control of amino acid biosynthesis protein 5 (zeige CAPS Proteine) (Gcn5 (zeige KAT2A Proteine)) and enhanced the binding of Gcn5 (zeige KAT2A Proteine) to the promoters of GATA binding protein 4 (GATA4 (zeige GATA4 Proteine)) and NK2 homeobox 5 (Nkx2.5 (zeige NKX2-5 Proteine)). In addition, Islet-1 downregulated DNA methyltransferase (zeige DNMT1 Proteine) (DNMT)1 (zeige DNMT1 Proteine) expression and reduced its binding to the GATA4 (zeige GATA4 Proteine) promoter.
Isl1beta is a key additional transcriptional factor for advancing the generation of insulin (zeige INS Proteine)-producing cells in the liver in combination with PDA (Pdx1 (zeige PDX1 Proteine), Neurod1 (zeige NEUROD1 Proteine), and Mafa (zeige MAFA Proteine)).
Overexpression of Islet1 affects the development and function of the cerebello-vestibular system, resulting in hyperactivity.
Results show that specific genomic loci associated with Islet-1 (Isl1) , LIM-homeobox 3 (Lhx3 (zeige LHX3 Proteine)), and LMO4 (zeige LMO4 Proteine) genes recruit the Isl1-Lhx3 (zeige LHX3 Proteine) complex to activate the transcription of Isl1, Lhx3 (zeige LHX3 Proteine), and Lmo4 (zeige LMO4 Proteine).
these results uncover a novel role for VEGF (zeige VEGFA Proteine) in controlling proper allocation of Isl1(+) cardiac progenitors to their respective descending lineages
CITED2 (zeige CITED2 Proteine) and ISL1 proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes.
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (zeige PAX6 Proteine) and the LIM protein (zeige PDLIM1 Proteine) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
Nkx2-5 and nkx2.7 genes restrict proliferation of heart field progenitors in the outflow tract, delimit the number of progenitors at the venous pole and pattern the sinoatrial node acting through Isl1 repression.
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.
prdm1a (zeige PRDM1 Proteine) Regulates sox10 (zeige SOX10 Proteine) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
, ISL1 transcription factor, LIM/homeodomain, (islet-1)
, domesticus (clone 1.7 kB) islet-1
, insulin gene enhancer protein ISL-1
, ISL1 transcription factor, LIM/homeodomain
, ISL1 transcription factor LIM/homeodomain (islet-1)
, ISL1 transcription factor, LIM/homeodomain 1
, isl-1 homeobox
, Insulin gene enhancer protein ISL-1
, Islet 1
, Lim-homeodomain protein Islet1
, insulin related protein
, insulin gene enhancer protein isl-1