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High IFI27 expression is associated with invasion in oral squamous cell carcinoma.
NEAT1 and the coding gene IFI27 were highly co-expressed and negatively correlated with dengue severity. Monitoring NEAT1and IFI27 expression in PBMC may be useful in understanding dengue virus-induced disease progression.
IFI27 was expressed in Influenza patients but not in Bacterial Respiratory Infection. IFI27 displayed 88% diagnostic accuracy (AUC) and 90% specificity in discriminating between Influenza and Bacterial Infections.
ISG12a inhibited HCV replication and potentiated the anti-HCV activity of IFN-alpha possibly through induced production of type I IFNs and activation of Jak/STAT signaling pathway independent of autophagy and cell apoptosis.
the ISG12 family of proteins has an important role for the apoptotic properties induced by type 1 interferon.
IFI27 mRNA level is reduced in peripheral blood mononuclear cells of immunoglobulin A nephropathy and membranous nephropathy patients.
IFI27 is involved in proliferation of skin keratinocytes both in vitro and in vivo.
Data indicate that AKT control TRAIL resistance of cancer cells through downregulation of interferon stimulated gene 12a (ISG12a) by MicroRNA-942 (miR-942).
We found that IFI27 is overexpressed in ovarian cancer and associated with patients' survival.
MiR-942 regulates hepatitis c virus-induced apoptosis of human hepatocytes by targeting ISG12a.
These results suggest that high basal ISG12a may inhibit Newcastle disease virus replication and oncolysis, while low basal ISG12a may allow sufficient Newcastle disease virus replication for induction of ISG12a.
Alterations in mechanisms associated with immune response and mitochondrial function that explain the up-regulation of IFI27 may provide an understanding of the pathways related to the intensification of fatigue during localized radiation therapy.
After inhibiting the autophagy, the expression of interferon b1 and IFI27 were decreased.
Patients with atypical teratoid/rhabdoid tumors show high p27 expression when angiogenesis and density of newly formed blood vessels were investigated.
interferon alpha-inducible protein 27 (IFI27) transcription stimulation was weaker in leiomyoma than myometrial cells
Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors.
IFI27 may be a novel biomarker of disease activity and tumor burden in patients with chronic myeloproliferative neoplasms
We identify IFI27, CCL2 and CXCL10 as sensitive biomarkers for the response of multiple sclerosis patients to IFN-beta.
Assessment of p21, p27, Bax, and cyclin E expression in tumor tissues have been reported to be useful as prognostic factors in head and neck squamous cell carcinoma.
Upregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis.
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (By similarity).
, interferon alpha-induced 11.5 kDa protein
, interferon alpha-inducible protein 27, mitochondrial
, interferon-stimulated gene 12a protein
, interferon alpha-inducible protein 27
, interferon, alpha-inducible protein 27 like 1
, interferon, alpha-inducible protein 27-like
, putative ISG12(a) protein