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NEAT1 and the coding gene IFI27 were highly co-expressed and negatively correlated with dengue severity. Monitoring NEAT1and IFI27 expression in PBMC may be useful in understanding dengue virus-induced disease progression.
IFI27 was expressed in Influenza patients but not in Bacterial Respiratory Infection. IFI27 displayed 88% diagnostic accuracy (AUC) and 90% specificity in discriminating between Influenza and Bacterial Infections.
ISG12a inhibited HCV replication and potentiated the anti-HCV activity of IFN-alpha (zeige IFNA Proteine) possibly through induced production of type I IFNs and activation of Jak (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathway independent of autophagy and cell apoptosis.
the ISG12 family of proteins has an important role for the apoptotic properties induced by type 1 interferon (zeige IFNA Proteine).
IFI27 mRNA level is reduced in peripheral blood mononuclear cells of immunoglobulin A nephropathy and membranous nephropathy patients.
IFI27 is involved in proliferation of skin keratinocytes both in vitro and in vivo.
Data indicate that AKT (zeige AKT1 Proteine) control TRAIL resistance of cancer cells through downregulation of interferon (zeige IFNA Proteine) stimulated gene 12a (ISG12a) by MicroRNA-942 (miR (zeige MLXIP Proteine)-942).
We found that IFI27 is overexpressed in ovarian cancer and associated with patients' survival.
MiR (zeige MLXIP Proteine)-942 regulates hepatitis c virus-induced apoptosis of human hepatocytes by targeting ISG12a.
Alterations in mechanisms associated with immune response and mitochondrial function that explain the up-regulation of IFI27 may provide an understanding of the pathways related to the intensification of fatigue during localized radiation therapy.
Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon (zeige IFNA Proteine)-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection.
up-regulation of Ifi27l2a in infected lungs is mainly due to the infiltration of macrophages and lymphocytes. Most surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not result in increased susceptibility to infections
Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 (zeige NR4A1 Proteine) nuclear receptors.
induced by Sindbis virus encephalitis to greater levels in brains of weanling mice than neonatal mice and significantly delayed death in the neonatal mice (interferon (zeige IFNA Proteine)- inducible protective protein, ISG12).
ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon (zeige IFNA Proteine)
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (By similarity).
, interferon alpha-induced 11.5 kDa protein
, interferon alpha-inducible protein 27, mitochondrial
, interferon-stimulated gene 12a protein
, interferon alpha-inducible protein 27
, interferon, alpha-inducible protein 27 like 1
, interferon, alpha-inducible protein 27-like
, putative ISG12(a) protein
, interferon alpha-inducible protein 27-like protein 2A
, interferon stimulated gene 12(b1)
, interferon-stimulated gene 12 protein