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Human HIF1A Protein expressed in Wheat germ - ABIN1306618
Vadivel, Alphonse, Etches, van Haaften, Collins, OReilly, Eaton, Thébaud: Hypoxia-inducible factors promote alveolar development and regeneration. in American journal of respiratory cell and molecular biology 2014
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Benzopyranyl 1,2,3-triazole compound inhibits HIF-1alpha by accelerating its degradation, and shows much potential as an anti-cancer agent through its ability to suppress tumor growth and angiogenesis.
via binding to hypoxia-responsive elements in MMP9 (zeige MMP9 Proteine) gene, HIF1alpha stimulated MMP9 (zeige MMP9 Proteine) expression, and therefore appeared as a prominent intermediary in HB-EGF (zeige HBEGF Proteine)-induced blood-brain barrier damage
that HIF-1 plays an important role in hyperglycemia-induced exacerbation of BBB disruption in ischemic stroke
HIF-1alpha/miR (zeige MLXIP Proteine)-210 pathway is strongly activated in VHL (zeige VHL Proteine) mutated paragangliomas, weakly activated in SDHx mutated PGLs (zeige PGLS Proteine), and not activated in VHLdel- and SDHxwt/VHLwt-PGLs (zeige PGLS Proteine).
Data indicate the important role of hypoxia inducible factor-1 (HIF-1) in the initial progression of immobilization-induced joint contracture, suggesting the possibility of molecular treatment to prevent the progression of joint contracture prior to intervention with physical therapy.
Data show that Tet1 (zeige TET1 Proteine) modulates HIF-2alpha (zeige EPAS1 Proteine) and HIF-1alpha through different mechanisms.
HIF1alpha-regulated profile defines a melanocyte-specific response under hypoxia, and demonstrates the role of HIF1alpha as an invasive cell state gatekeeper in regulating cellular metabolism, chromatin and transcriptional regulation, vascularization, and invasion.
omega-alkynyl arachidonic acid may promote the anti-inflammatory M2 polarization of macrophages in acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1alpha and iNOS (zeige NOS2 Proteine).
Herein we report that TGM1 (zeige TGM1 Proteine) is a HIF-1-regulated gene that is associated with the upregulation of airway epithelial junction proteins, supporting a protective role for HIF-1 in the lung.
the role of hypoxia-inducible factor-1 for myeloid cell function and immune response during colitis, was investigated.
Our experiments revealed that long-term (24 h), but not short-term hypoxia led to the induction of NDRG1 (zeige NDRG1 Proteine) expression in human glioma cell lines. NDRG1 (zeige NDRG1 Proteine) expression was found to correlate with the protein expression of HIF-1alpha, SP1 (zeige PSG1 Proteine), CEBPalpha, YB-1 (zeige YBX1 Proteine) and Smad7 (zeige SMAD7 Proteine)
Mechanistically, miR (zeige MLXIP Proteine)-543 inhibited PRMT9 (zeige FBXO11 Proteine)-enhanced cell oxidative phosphorylation, while miR (zeige MLXIP Proteine)-543 depletion promoted PRMT9 (zeige FBXO11 Proteine)-increased HIF-1alpha instability and inhibited glycolysis in osteosarcoma (OS) cells. Clinically, miR (zeige MLXIP Proteine)-543 expression was negatively correlated with PRMT9 (zeige FBXO11 Proteine) expression in OS tissues.
Data show that cytomegalovirus encoded chemokine receptor US28 (US28) signaling in activation of the HIF-1alpha/PKM2 feedforward loop in fibroblasts and glioblastoma cells.
Results imply that HIF-1alpha, in association with LHBs, induces MDR1 overexpression, which may contribute to the pathogenic changes in chronic hepatitis B infection.
these studies provide evidence that adipocytes drive metabolic reprogramming of prostate cancer cells via oxygen-independent mechanism of HIF-1alpha activation
VHL (zeige VHL Proteine) missense mutations in the p53 (zeige TP53 Proteine) binding domain show different effects on p53 (zeige TP53 Proteine) signaling and HIFalpha degradation in clear cell renal cell carcinoma (zeige MOK Proteine), enhancing tumor cell survival.
Hypoxia-induced epithelial mesenchymal transition-like cancer stem cells rely on HIF-1alphato activate Snail (zeige SNAI1 Proteine), which may result in recurrence and metastasis of gastric cancer.
Everolimus sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1alpha and sphingosine kinase 1 (zeige SPHK1 Proteine) expression.
a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (zeige HSP70 Proteine)) was noted
Induction of ischemic osteonecrosis results in IL-6 (zeige IL6 Proteine) production in the articular cartilage through an HIF-1-dependent pathway.
Upregulation of VEGF (zeige VEGFA Proteine) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
HIF-1alpha activates Sox9 (zeige SOX9 Proteine) expression and enhances Sox9 (zeige SOX9 Proteine)-mediated transcriptional activity.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
immunostaining for HIF-1alpha and HIF-2alpha (zeige EPAS1 Proteine) was observed during endochondral ossification, whereas only HIF-2alpha (zeige EPAS1 Proteine) was present at sites of intramembranous ossification
Downregulation of miR (zeige MYLIP Proteine)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (zeige SIRT1 Proteine) and recapitulates hypoxia preconditioning in cardiac myocytes.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.
inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow
Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.
hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity
VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself
Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
HIF-1alpha-induced HSP70 (zeige HSP70 Proteine) overexpression increased the expression levels of ECM (zeige MMRN1 Proteine) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (zeige HSP70 Proteine) expression
Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.
Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.
HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.
Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1
Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.
rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.
Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion
Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide (zeige SQRDL Proteine) resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide (zeige SQRDL Proteine) was naturally selected in certain habitats.
blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.
HIF-1-mediated activation of 5-HT (zeige DDC Proteine) signalling promotes axon regeneration by activating both the RhoA (zeige RHOA Proteine) and cAMP pathways.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (zeige FMO2 Proteine)).
AMPK (zeige PRKAA1 Proteine) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (zeige ROS1 Proteine)
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (zeige PRKAA1 Proteine) compromised C. elegans dauer larvae.
These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
Data indicate that genes sqrd-1, ethe-1 (zeige ETHE1 Proteine), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (zeige SQRDL Proteine) and hydrogen cyanide.
Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, HIF1 alpha
, Hypoxia-inducible factor 1 alpha
, hypoxia-inducible factor 1-alpha
, ARNT-interacting protein
, ARNT interacting protein
, PAS domain-containing protein 8
, basic-helix-loop-helix-PAS protein MOP1
, class E basic helix-loop-helix protein 78
, hypoxia-inducible factor 1 alpha isoform I.3
, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
, hypoxia-inducible factor1alpha
, member of PAS protein 1
, member of PAS superfamily 1
, hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha subunit
, hypoxia inducible factor 1, alpha subunit