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these data indicate CCL19/CCR7 (zeige CCR7 Proteine) contributes to proliferation and invasion of ESCs (zeige NR2E3 Proteine), which are conducive to the pathogenesis of endometriosis through activating PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway
The research findings demonstrate for the first time that the chemokines CCL19, CCL21 (zeige CCL21 Proteine) and CCR7 (zeige CCR7 Proteine) play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
breast cancers-derived soluble factors increase the migration of DCs toward CCL19.
The migratory index to the CCR7 (zeige CCR7 Proteine) ligands, CCL19 and CCL21 (zeige CCL21 Proteine), was higher in T-cells from donors whose recipients will develop GvHD.
Study confirmes that CCL19 induces the invasion and migration of breast cancer cells through the expression of markers of epithelial-mesenchymal transition.
findings connect NOTCH1 (zeige NOTCH1 Proteine), DUSP22 (zeige DUSP22 Proteine), and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 (zeige NOTCH1 Proteine) mutations in CLL.
Deletion of this extended C-terminus reduces CCL21 (zeige CCL21 Proteine)'s affinity for heparin and transferring the CCL21 (zeige CCL21 Proteine) C-terminus to CCL19 enhances heparin binding mainly through non-specific, electrostatic interactions
CCL19 is significantly overexpressed in patients with unstable carotid atherosclerotic plaques and may be a possible novel biomarker for identifying high-risk patients in whom more urgent intervention may be indicated.
CrkL (zeige CRKL Proteine) regulates CCL19 and CCR7 (zeige CCR7 Proteine)-induced epithelial-to-mesenchymal transition via ERK (zeige EPHB2 Proteine) signaling pathway in epithelial ovarian carcinoma patients.
observed significantly higher concentrations of IL-8 (zeige IL8 Proteine) (p < 0.001), MCP-1 (zeige CCL2 Proteine) (p = 0.014), and MIP (zeige TNPO1 Proteine)-3beta (p = 0.022) in the PF of women with endometriosis than in the controls.
These data show that CCR7 (zeige CCR7 Proteine)-CCL19/CCL21 (zeige CCL21 Proteine) axis facilitates retention CD4 (zeige CD4 Proteine)(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
the white pulp regions of ME7-infected spleens were smaller, and contained markedly diminished T zones, as compared to control spleens. Although lymphoid tissue inducer cells were not affected, the expression of both CCL19 and CCL21 (zeige CCL21 Proteine) was decreased.
a comprehensive model of CCL19 and CCL21 (zeige CCL21 Proteine) transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 (zeige CCL21 Proteine) accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 (zeige CCL21 Proteine) gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
The beneficial effects of epicatechin in ameriorating diet-induced obesity and insulin (zeige INS Proteine) resistance could be mediated, at least in part, by marked suppression of CCL19 expression.
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 (zeige CCR7 Proteine) and its ligands, CCL19 and CCL21 (zeige CCL21 Proteine), as well as on the nuclear factor-Kappa B (NF-kappaB (zeige NFKB1 Proteine)) pathway in a mouse model of asthma.
Interferon-gamma (IFN-gamma (zeige IFNG Proteine)) and interleukin-12 (IL-12 (zeige IL12A Proteine)) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19.
Modulation of the chemokines CCL19 and CCL21 (zeige CCL21 Proteine) represents a potent immunoregulatory treatment approach, and thus represents a novel therapeutic target to stabilize atherosclerotic lesions.
CCL19 (ELC) improves TH1 (zeige HAND1 Proteine)-polarized immune responses and protective immunity in a murine Her2/neu (zeige ERBB2 Proteine) DNA vaccination model.
study shows that CCL19/21 and its possible signaling through CXCR3 (zeige CXCR3 Proteine) are required for the development of thymic metallophilic macrophages
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
C-C motif chemokine 19
, CC chemokine ligand 19
, CK beta-11
, EBI1 ligand chemokine
, EBI1-ligand chemokine
, beta chemokine exodus-3
, beta-chemokine exodus-3
, epstein-Barr virus-induced molecule 1 ligand chemokine
, macrophage inflammatory protein 3 beta
, macrophage inflammatory protein 3-beta
, small inducible cytokine subfamily A (Cys-Cys), member 19
, small-inducible cytokine A19
, chemokine (C-C motif) ligand 19
, CCL19 chemokine
, small inducible cytokine A19
, chemokine CCL19/MIP-3BETA
, EBI-1 ligand chemokine
, EBV-induced molecule 1 ligand chemokine
, chemokine CCL19