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In the present study, high levels of CC motif ligand 19 (CCL19), signaling pathways such as Tolllike receptor 4 (TLR4)/nuclear factorkappaB (NFkappaB), and proinflammatory factors including interleukin6 (IL6) and tumor necrosis factora (TNFa) were detected in Nonalcoholic fatty liver disease patients
these data indicate CCL19/CCR7 contributes to proliferation and invasion of ESCs, which are conducive to the pathogenesis of endometriosis through activating PI3K/Akt pathway
The research findings demonstrate for the first time that the chemokines CCL19, CCL21 and CCR7 play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
breast cancers-derived soluble factors increase the migration of DCs toward CCL19.
The migratory index to the CCR7 ligands, CCL19 and CCL21, was higher in T-cells from donors whose recipients will develop GvHD.
Study confirmes that CCL19 induces the invasion and migration of breast cancer cells through the expression of markers of epithelial-mesenchymal transition.
findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 mutations in CLL.
Deletion of this extended C-terminus reduces CCL21's affinity for heparin and transferring the CCL21 C-terminus to CCL19 enhances heparin binding mainly through non-specific, electrostatic interactions
CCL19 is significantly overexpressed in patients with unstable carotid atherosclerotic plaques and may be a possible novel biomarker for identifying high-risk patients in whom more urgent intervention may be indicated.
CrkL regulates CCL19 and CCR7-induced epithelial-to-mesenchymal transition via ERK signaling pathway in epithelial ovarian carcinoma patients.
observed significantly higher concentrations of IL-8 (p < 0.001), MCP-1 (p = 0.014), and MIP-3beta (p = 0.022) in the PF of women with endometriosis than in the controls.
The solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive.
Our findings serve to elucidate the molecular mechanisms underlying the resistin induction of CCL19 expression in ECs and the shear-stress protection against this induction.
The mRNA levels of CCL19/CCL21 in ankylosing spondylitis hip ligament were significantly higher than in osteoarthritis ligament.
Serum CCL19 and CCL21 were up-regulated during Rickettsia conorii infection.
CCL19 promoted monocyte adhesion to HUVEC cells. CCL19 rs2227302 was associated with coronary artery disease in a Chinese Han population.
CCL19 is an antimicrobial protein with bacteriocidal activity against E. coli.
CCL19 (rather than CCL21) may contribute to the accumulation of dendritic cells and macrophages in the inflamed lungs of patients with eosinophilic pneumonia.
CIP4 is expressed at abnormally high levels in CLL cells, where it is required for CCL19-induced chemotaxis.
Serum CCL19 measurement is a new hallmark of the B cell-mediated rheumatoid arthritis subtype and may predict clinical response to rituximab.
Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis.
We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 x 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs... Following treatment of mice with 7 x 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors.
These data show that CCR7-CCL19/CCL21 axis facilitates retention CD4(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
the white pulp regions of ME7-infected spleens were smaller, and contained markedly diminished T zones, as compared to control spleens. Although lymphoid tissue inducer cells were not affected, the expression of both CCL19 and CCL21 was decreased.
a comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
The beneficial effects of epicatechin in ameriorating diet-induced obesity and insulin resistance could be mediated, at least in part, by marked suppression of CCL19 expression.
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 and CCL21, as well as on the nuclear factor-Kappa B (NF-kappaB) pathway in a mouse model of asthma.
increased expression in mononuclear inflammatory cells isolated from the brain during active stage of experimental autoimmune encephalomyelitis
Interferon-gamma (IFN-gamma) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19.
Modulation of the chemokines CCL19 and CCL21 represents a potent immunoregulatory treatment approach, and thus represents a novel therapeutic target to stabilize atherosclerotic lesions.
CCL19 (ELC) improves TH1-polarized immune responses and protective immunity in a murine Her2/neu DNA vaccination model.
study shows that CCL19/21 and its possible signaling through CXCR3 are required for the development of thymic metallophilic macrophages
CCL19 and CCL21 induce prompt Ab responses to antigen, and negatively regulate helper T cell responses in vivo.
CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in peripheral lymph nodes.
Complete deficiency of CCL19 & CCL21 but not CCL19 alone was associated with abnormal frequencies & localization of DC in naive lymph nodes. CCL19 was not required for DC migration from the skin, full DC maturation or efficient T-cell priming.
Systemic delivery of an immune-activating signal using CCL19 transduced embryonic endothelial progenitor cells suppresses metastasis of murine ovarian cancer.
CCL19 homeostatic chemokine performs distinct functions that cooperate with CCL21 and CXCL13 to mediate effective expression of immunity against Mycobacterium tuberculosis infection.
Ectopic expression of Scya19 in pancreatic islets leads to small infiltrates composed of lymphocytes and dendritic cells and containing high endothelial venules and stromal cells; its expression with Sdf1 is sufficient to mediate cell recruitment in vivo.
CCL19 induces rapid change in dendritic cell morphology, inducing dendritic extensions, while CCL21 inhibits CCL19-induced dendritic extensions.
Intratumor injection of recombinant ELC/CCL19 shows an interferon-gamma-dependent reduction in tumor burden.
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
C-C motif chemokine 19
, CC chemokine ligand 19
, CK beta-11
, EBI1 ligand chemokine
, EBI1-ligand chemokine
, beta chemokine exodus-3
, beta-chemokine exodus-3
, epstein-Barr virus-induced molecule 1 ligand chemokine
, macrophage inflammatory protein 3 beta
, macrophage inflammatory protein 3-beta
, small inducible cytokine subfamily A (Cys-Cys), member 19
, small-inducible cytokine A19
, chemokine (C-C motif) ligand 19
, CCL19 chemokine
, small inducible cytokine A19
, chemokine CCL19/MIP-3BETA
, EBI-1 ligand chemokine
, EBV-induced molecule 1 ligand chemokine
, chemokine CCL19