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Ectopically expressed in Drosophila Bcl-rambo localizes to mitochondria, induces apoptosis and atrophied wing, split thorax, and rough eye phenotypes.
This study showed that Bcl-2-like protein 13 (Bcl2-L-13) induces mitochondrial fragmentation and mitophagy in mammalian cells.
Bcl2L13 binds to proapoptotic ceramide synthases 2 (CerS2 (zeige CERS2 ELISA Kits)) and 6 (CerS6) via a unique C-terminal 250-aa sequence located between its Bcl-2 (zeige BCL2 ELISA Kits) homology and membrane anchor domains and blocks homo- and heteromeric CerS2 (zeige CERS2 ELISA Kits)/6 complex formation and activity.
Bcl-rambo is a pro-apoptotic member of the Bcl-2 (zeige BCL2 ELISA Kits) family, inducing the permeability transition via interaction with the adenine nucleotide translocator (zeige SLC25A4 ELISA Kits) (ANT).
investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan
SidF contributes to apoptosis resistance in L. pneumophila-infected cells by specifically interacting with and neutralizing the effects of BNIP3 (zeige BNIP3 ELISA Kits) and Bcl-rambo, two proapoptotic members of Bcl2 (zeige BCL2 ELISA Kits) protein family.
MicroRNA-124 and microRNA-137 cooperatively control caspase-3 (zeige CASP3 ELISA Kits) activity through BCL2L13 in hippocampal neural stem cells.
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene.
BCL2-like 13 (apoptosis facilitator)
, bcl-2-like protein 13
, apoptosis facilitator
, mitochondria located 1 homolog
, protein Mil1