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BPGAP1 (zeige ARHGAP8 Proteine) provides a crucial spatiotemporal checkpoint where JNK (zeige MAPK8 Proteine) and MP1 (zeige PITRM1 Proteine)/MEK1 (zeige MAP2K1 Proteine) work in concert to regulate endosomal and nuclear ERK (zeige EPHB2 Proteine) signaling in cell proliferation control.
Pin1 (zeige PIN1 Proteine) regulates BPGAP1 (zeige ARHGAP8 Proteine) function in Rho and Erk (zeige EPHB2 Proteine) signalling, with active Mek2 (zeige MAP2K2 Proteine) serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP (zeige ARHGAP1 Proteine), Pin1 (zeige PIN1 Proteine) and Erk (zeige EPHB2 Proteine) in the regulation of cell migration.
mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines
It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 (zeige PRR5L Proteine) results in the co-immunoprecipitation of other mTORC2 (zeige CRTC2 Proteine) subunits, but not Raptor (zeige RPTOR Proteine), a specific component of mTORC1.
The inhibition of Akt (zeige AKT1 Proteine) and S6K1 (zeige RPS6KB1 Proteine) phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (zeige PDGFRB Proteine) (PDGFRbeta).
BPGAP1 (zeige ARHGAP8 Proteine) has a role in regulating cell dynamics with BNIP-2 (zeige BNIP2 Proteine) and Cdc42GAP (zeige ARHGAP1 Proteine) homology/Sec14p-like, proline-rich, and GTPase-activating protein (zeige RASA1 Proteine) domains of BPGAP1 (zeige ARHGAP8 Proteine)
RhoGAP (zeige ARHGAP1 Proteine) functionally interacts with cortactin (zeige CTTN Proteine) and represents a novel determinant in the regulation of cell dynamics.
ARHGAP8 (zeige ARHGAP8 Proteine) expression was up-regulated in the majority of primary colorectal tumors analyzed in this work.
BPGAP1 (zeige ARHGAP8 Proteine) is a novel RhoGAP (zeige ARHGAP1 Proteine) that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 (zeige BNIP2 Proteine) and Cdc42GAP (zeige ARHGAP1 Proteine) homology domains.
findings reveal a concomitant activation of endocytosis and ERK (zeige EPHB2 Proteine) signaling by BPGAP1 (zeige ARHGAP8 Proteine) via the coupling of its proline-rich region, which targets EEN (zeige SH3GL1 Proteine) and its functional GAP domain
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
BCH domain-containing Cdc42GAP-like protein
, BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1
, rho GTPase-activating protein 8
, rho-type GTPase-activating protein 8
, proline-rich protein 5
, protein observed with Rictor-1
, Rho GTPase activating protein 8
, Protor-2 homolog
, proline rich 5 (renal)
, proline rich protein 5