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anti-Human PPP2R2B Antikörper:
anti-Rat (Rattus) PPP2R2B Antikörper:
anti-Mouse (Murine) PPP2R2B Antikörper:
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PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
New pathogenic threshold of PPP2R2B CAG-43 to be pathogenic for SCA12 diagnosis.
CAG triplet repeat expansion has been found in untranslated region of SCA12 gene in Indian spinocerebellar ataxia 12 patients.
Thus, Fcp1 (zeige CTDP1 Antikörper) coordinates Cdk1 (zeige CDK1 Antikörper) and Gwl (zeige MASTL Antikörper) inactivation to derepress PP2A (zeige PPP2R4 Antikörper)-B55 (zeige MINK1 Antikörper), generating a dephosphorylation switch that drives mitosis progression.
investigated CAG copies within PPP2R2B in 29 patients with spinocerebellar ataxia who are excluded from the most common subtypes; 3 patients carried 53, 46 and 54 CAG repeats respectively, while the other 26 cases harbored CAG repeats less than 30
IER5 (zeige IER5 Antikörper) functions as a positive feedback regulator of HSF1 (zeige HSF1 Antikörper) and that this process involves PP2A (zeige PPP2R4 Antikörper)/B55 (zeige MINK1 Antikörper) and HSF1 (zeige HSF1 Antikörper) dephosphorylation.
Bcl-2 (zeige BCL2 Antikörper) phosphorylation at Ser70 by selective tyrosine nitration of PP2A (zeige PPP2R4 Antikörper)-B56delta stabilizes its antiapoptotic activity
Inactivation of protein-phosphatase 2A causing hyperphosphorylation of paraprotein targets in monoclonal gammopathy of undetermined significance, multiple myeloma and Waldenstrom's macroglobulinemia is due to an exchange of its regulatory subunits
Identification of the adenovirus E4orf4 protein binding site on the B55alpha (zeige PPP2R2A Antikörper) and Cdc55 regulatory subunits of PP2A (zeige PPP2R4 Antikörper): Implications for PP2A (zeige PPP2R4 Antikörper)
We demonstrate that PP2A/B55 is required for Gwl dephosphorylation at the essential Cdk site Thr194. Ensa/ARPP19 dephosphorylation is mediated by the RNA
PP2A (zeige PPP2R4 Antikörper)-B55beta promotes cyclin E1 (zeige CCNE1 Antikörper) overexpression by antagonizing its degradation and its inhibition could represent a therapeutic mechanism for abrogating cyclin E1 (zeige CCNE1 Antikörper) function in cancers
TRPV1 (zeige TRPV1 Antikörper) activation in endothelial cells may elicit a Ca(2 (zeige CA2 Antikörper)+) -dependent effect on PP2B-PKC (zeige PKC Antikörper) signalling, which leads to dephosphorylation of eNOS (zeige NOS3 Antikörper)
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (zeige FYN Antikörper).
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
equilibrium between CDK1 (zeige CDK1 Antikörper) and PP2A specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.
inhibition of PP2A-B55delta results from Ensa (zeige ENSA Antikörper), that is phosphorylated in mitosis by the protein kinase (zeige CSNK1D Antikörper) Greatwall (zeige MASTL Antikörper); this converts Ensa (zeige ENSA Antikörper) into specific inhibitor of PP2A-B55delta; this pathway represents a previously unknown element in mitosis control
study describes how Gwl (zeige MASTL Antikörper) activation results in PP2A inhibition; identified Arpp19 (zeige ARPP19 Antikörper) and alpha-Endosulfine (zeige ENSA Antikörper) that, when phosphorylated by Gwl (zeige MASTL Antikörper), associate with and inhibit PP2A promoting mitotic entry
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.
PP2A subunit B isoform B55-beta
, PP2A subunit B isoform PR55-beta
, PP2A subunit B isoform R2-beta
, PP2A, subunit B, B-beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
, serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform
, serine/threonine protein phosphatase 2A, neuronal isoform
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
, BRbeta B-regulatory subunit of protein phosphatase 2A
, PP2A subunit B isoform BRB
, PP2A subunit B isoform beta
, PP2A, subunit B, B55-beta isoform
, PP2A, subunit B, BRB isoform
, PP2A, subunit B, PR55-beta isoform
, PP2A, subunit B, R2-beta isoform
, phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
, protein phosphatase 2A 55 kDa regulatory subunit, beta isoform
, beta isoform of regulatory subunit B55, protein phosphatase 2
, protein phosphatase-2A subunit-beta
, protein phosphatase 2, regulatory subunit B, beta
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like