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High PI3K expression is sensitive to initial injury intensity induced by freeze damage.
excessive proliferation of endometrial epithelial cells was observed in Pik3cad/d mice. Our studies suggest that Pik3ca has a critical role in uterine gland development and female fertility
Long latency DMBA induced mouse mammary tumors reproduce the molecular profile of human luminal breast carcinomas, displaying a high incidence of activating Pik3caH1047 and loss of function Pten mutations.
Data show that the phosphoinositide 3-kinase (PI3K) inhibitor BKM120 led to a precipitous drop in DNA synthesis within 8 h of drug treatment, whereas DNA synthesis in normal tissues was less affected.
Using genetic inactivation of the growth and metabolism regulator, Pik3ca (encoding PIK3CA also known as p110alpha, alpha/+), the interplay between the maternal genome and the fetal genome on placental phenotype, was examined.
these results identify the PI3K-GSK3-SMAD1 (zeige SMAD1 Proteine) axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
Data suggest a critical role for KDM3A (zeige KDM3A Proteine) in the PI3K/AP-1 (zeige JUN Proteine) oncogenic axis and propose a novel strategy for inhibition of KDM3A (zeige KDM3A Proteine) against liver tumor development under PI3K pathway activation.
Data show that tumors lacking PSMA had less than half the abundance of type 1 insulin-like growth factor receptor (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK-ERK1/2 signaling.
Both PIK3CA mutants H1047R and E545K are able to activate the AKT/mTOR pathway. An intact AKT2/mTOR complex 1 cascade is required for tumourigenesis induced by H1047R/c-Met or E545K/c-Met in the liver in mice.
Loss of HDAC (zeige HDAC3 Proteine)-mediated repression and gain of NF-kappaB (zeige NFKB1 Proteine) activation underlie cytokine induction in ARID1A- and PIK3CA-mutation-driven ovarian cancer.
The findings suggest that PIK3CA mutation has no significant effects on overall survival and on disease-free survival in esophageal squamous cell carcinoma patients. (Meta-analysis)
Suggest that PIK3CA gene mutations could act as a prognostic biomarker in Northwest Chinese esophageal squamous cell carcinoma patients.
our data point to a targetable Axl (zeige AXL Proteine)-PI3 kinase-PD-L1 (zeige CD274 Proteine) axis that is highly associated with radiation resistance
there was no association between PIK3CA mutation and expression, or of other related genes, namely PIK3CB, PIK3CD, PIK3CG, and PTEN. Mutation of PIK3CA might alter calmodulin expression and other genetic pathways
This study, for the first time segregates atypical verruciform lesions by virtue of a unique genotype (PIK3CA mutant/TP53 (zeige TP53 Proteine) wild type) illustrating an example of progression to a TP53 (zeige TP53 Proteine)-mutated keratinizing carcinoma.
Increased levels of FGFR3 (zeige FGFR3 Proteine) and PIK3CA mutated DNA in urine and plasma are indicative of later progression and metastasis in bladder cancer.
KRAS and PIK3CA genotype may be considered as negative predictive markers and should carry out the analysis expeditiously.
PIK3CA mutant and -wildtype gastric tumor subclones are skilled to metastasize independently to different regional lymph nodes.
these results suggest that PIK3CA mutation may be a new predictive biomarker for celecoxib efficacy treatment in breast cancer
PIK3CA mutation was associated with treatment response in breast cancer.
There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.
PI3K has a role in activation of 5'-AMP (zeige TMPRSS5 Proteine)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
Production of PtdIns3P by PI3K-C2alpha (zeige PIK3C2A Proteine) is required for acquisition of fusion competence in neurosecretion.
crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
phosphoinositide-3-kinase, catalytic, alpha polypeptide
, Phosphoinositide-3-kinase, catalytic, alpha polypeptide
, PI3-kinase subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphoinositide-3-kinase catalytic alpha polypeptide
, ptdIns-3-kinase subunit alpha
, ptdIns-3-kinase subunit p110-alpha
, serine/threonine protein kinase PIK3CA
, PI3-kinase p110 subunit alpha
, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
, ptdIns-3-kinase p110
, phosphoinositide 3-kinase catalytic subunit