anti-Human PDPK1 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended PDPK1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antikörper
  • pdpk1
  • MGC82080
  • PDK1
  • PDPK2
  • PRO0461
  • Pdk1
  • si:zfos-979f1.3
  • 1210
  • BG02759
  • CG1201
  • CG1210
  • DSTPK61
  • Dmel\\CG1210
  • Dstpk61
  • PDK
  • PDK-1
  • PDK1/Pk61C
  • PK61C
  • Pk61C
  • Pk61C/PDK1
  • dPDK-1
  • dPDK1
  • dSTPK61
  • pk61c
  • 3'-phosphoinositide-dependent protein kinase 1
  • 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
  • ATPDK1
  • AtPDK1
  • T32M21.110
  • T32M21_110
  • 3-phosphoinositide dependent protein kinase 1
  • 3-phosphoinositide dependent protein kinase 1 L homeolog
  • 3-phosphoinositide dependent protein kinase-1
  • 3-phosphoinositide-dependent protein kinase 1
  • pyruvate dehydrogenase kinase, isozyme 1
  • pyruvate dehydrogenase kinase 1
  • Phosphoinositide-dependent kinase 1
  • 3'-phosphoinositide-dependent protein kinase 1
  • PDPK1
  • pdpk1.L
  • pdpk1
  • Pdpk1
  • LOC100380750
  • pdk1
  • PDK1
  • Pdk1
  • pdk-1
Epitop
pSer241
57
35
32
27
27
26
18
17
15
15
15
15
7
7
6
6
6
5
4
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
462
218
218
19
13
12
11
11
6
5
4
3
2
1
1
1
1
1
1
1
Wirt
Kaninchen
381
73
16
Klonalität
Polyklonal
Konjugat
Dieser PDPK1 Antikörper ist unkonjugiert
19
17
16
11
11
7
7
7
7
7
7
7
7
7
7
6
5
5
4
4
3
3
3
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
311
158
100
90
66
64
40
31
22
10
7
5
3
2
1
Optionen
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Bilder

Produktnummer ABIN744668
$ 340.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
14.109145 ABIN4344572 IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 1
14.109145 ABIN954076 EIA IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
14.109145 ABIN4344570 ICC IF IHC IHC (p) WB Rabbit pSer241 Anmelden zum Anzeigen Polyclonal
14.109145 ABIN214664 IHC (p) ELISA Rabbit pSer241 Anmelden zum Anzeigen Polyclonal
14.109145 ABIN615271 IHC (p) WB Rabbit AA 269-320 Anmelden zum Anzeigen Polyclonal
14.109145 ABIN4344574 ELISA FACS ICC IF IHC IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 4A11
14.109145 ABIN4344641 ICC IF IHC IHC (p) Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN3043600 IHC (p) WB Rabbit IgG AA 524-556, C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN3044043 IHC (p) WB Rabbit IgG AA 408-421, C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN196616 IF IHC (p) WB Rabbit pSer241 Anmelden zum Anzeigen Polyclonal 4
1 ABIN197100 IF IHC (p) WB Rabbit Ser241 Anmelden zum Anzeigen Polyclonal 5
1 ABIN962046 IHC (p) ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN711116 IF (p) IHC (p) WB Rabbit IgG pTyr9 Anmelden zum Anzeigen Polyclonal
1 ABIN682948 IF (p) IHC (p) WB Rabbit IgG pTyr373, pTyr376 Anmelden zum Anzeigen Polyclonal
1 ABIN1737955 IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2889054 IHC (p) ELISA WB Rabbit IgG AA 210-259 Anmelden zum Anzeigen Polyclonal
1 ABIN2888512 IHC (p) ELISA WB Rabbit IgG pSer241 Anmelden zum Anzeigen Polyclonal
1 ABIN1108608 EIA FACS IF IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 4A11 3
1 ABIN127128 IHC (p) IP WB Rabbit Anmelden zum Anzeigen Polyclonal
1 ABIN303441 EIA IHC (p) Rabbit AA 236-248, pSer241 Anmelden zum Anzeigen Polyclonal

General

Antigen 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antikörper
Epitop pSer241
(57), (35), (32), (27), (27), (26), (18), (17), (15), (15), (15), (15), (7), (7), (6), (6), (6), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(462), (218), (218), (19), (13), (12), (11), (11), (6), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Wirt Kaninchen
(381), (73), (16)
Klonalität
Polyklonal
Konjugat Dieser PDPK1 Antikörper ist unkonjugiert
(19), (17), (16), (11), (11), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (5), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(311), (158), (100), (90), (66), (64), (40), (31), (22), (10), (7), (5), (3), (2), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PDPK1 Antikörper

Target Details PDPK1 Anwendungsinformationen Handhabung Referenzen für anti-PDPK1 Antikörper (ABIN744668) Bilder
Spezifität This phosphorylation site is homologous to Ser244 in Mouse and Rat.
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human PDK1 around the phosphorylation site of Ser241
Isotyp IgG

Target Details PDPK1

Produktdetails anti-PDPK1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-PDPK1 Antikörper (ABIN744668) Bilder zurück nach oben
Antigen
Andere Bezeichnung Pdk1 (PDPK1 Antibody Abstract)
Hintergrund

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses.

Subcellular location: Cytoplasm, Membrane bound

Synonyms: PDK1, PDPK2, PDPK2P, PRO0461, 3-phosphoinositide-dependent protein kinase 1, hPDK1, PDPK1

Gen-ID 5170
UniProt O15530
Forschungsgebiet Signaling, Cytoskeleton, Microfilaments, Kinases/Phosphatases
Pathways PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals

Anwendungsinformationen

Produktdetails anti-PDPK1 Antikörper Target Details PDPK1 Handhabung Referenzen für anti-PDPK1 Antikörper (ABIN744668) Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PDPK1 Antikörper Target Details PDPK1 Anwendungsinformationen Referenzen für anti-PDPK1 Antikörper (ABIN744668) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-PDPK1 Antikörper (ABIN744668)

Produktdetails anti-PDPK1 Antikörper Target Details PDPK1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: "Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy." in: Epilepsy research, Vol. 112, pp. 137-49, 2015

Bilder

Produktdetails anti-PDPK1 Antikörper Target Details PDPK1 Anwendungsinformationen Handhabung Referenzen für anti-PDPK1 Antikörper (ABIN744668) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Mouse bone lysates probed with Rabbit Anti-PDK1(ser241) Polyclonal Antibody, Unconjug...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) paraformaldehyde-fixed, paraffin embedded human live carcinoma tissue, Antigen retrie...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) paraformaldehyde-fixed, paraffin embedded human breast carcinoma tissue, Antigen retr...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boil...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Paraformaldehyde-fixed, paraffin embedded rat kidney tissue, Antigen retrieval by boi...
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody (ABIN744668) Lane 1: Mouse brain lysates, Lane 2: Mouse heart lysates probed with PDK1(Ser241) Pol...