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anti-Human NCF1 Antikörper:
anti-Mouse (Murine) NCF1 Antikörper:
anti-Rat (Rattus) NCF1 Antikörper:
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Human Monoclonal NCF1 Primary Antibody für IF, WB - ABIN967919
Ago, Nunoi, Ito, Sumimoto: Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating in The Journal of biological chemistry 1999
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Human Monoclonal NCF1 Primary Antibody für IF, WB - ABIN967918
Chanock, el Benna, Smith, Babior: The respiratory burst oxidase. in The Journal of biological chemistry 1994
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Human Polyclonal NCF1 Primary Antibody für WB - ABIN2801889
Volpp, Nauseef, Donelson, Moser, Clark: Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Mouse (Murine) Polyclonal NCF1 Primary Antibody für IHC, ELISA - ABIN1531722
Lee, Ko, Jeong, Park, Kim: β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. in Journal of neuroinflammation 2015
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Human Polyclonal NCF1 Primary Antibody für IF (p), IHC (p) - ABIN1385194
Chen, Ye, Zhang, Tang, Li, Lu, Wu, Yu, Kou: Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils. in International journal of molecular sciences 2016
Human Polyclonal NCF1 Primary Antibody für IF (p), IHC (p) - ABIN1387732
Almajdoob, Hossain, Anand-Srivastava: Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling. in Vascular pharmacology 2018
Human Polyclonal NCF1 Primary Antibody für IHC, ELISA - ABIN1531718
Kröller-Schön, Steven, Kossmann, Scholz, Daub, Oelze, Xia, Hausding, Mikhed, Zinßius, Mader, Stamm, Treiber, Scharffetter-Kochanek, Li, Schulz, Wenzel, Münzel, Daiber: Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species - studies in white blood cells and in animal models. in Antioxidants & redox signaling 2013
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Mouse (Murine) Polyclonal NCF1 Primary Antibody für ELISA, IF - ABIN1586076
Kim, Ryu, Kang: Status epilepticus induces vasogenic edema via tumor necrosis factor-α/ endothelin-1-mediated two different pathways. in PLoS ONE 2014
Human Polyclonal NCF1 Primary Antibody für ELISA, IHC (p) - ABIN256632
Davidson-Moncada, Lopez-Lluch, Segal, Dekker: Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils. in The Biochemical journal 2002
Mouse (Murine) Polyclonal NCF1 Primary Antibody für ELISA, WB - ABIN4338257
Roos, Kuhns, Maddalena, Bustamante, Kannengiesser, de Boer, van Leeuwen, Köker, Wolach, Roesler, Malech, Holland, Gallin, Stasia: Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update). in Blood cells, molecules & diseases 2010
patients with hereditary p47phox deficiency show reduced platelet activation suggesting a role for this Nox cytosolic subunit in platelet activation.
Decreased and increased copy numbers of NCF1 predispose to and protect against SLE.
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (zeige HCK Antikörper)-dependent activation of PKCdelta (zeige PKCd Antikörper), which stimulates PKCgamma (zeige PRKCG Antikörper), resulting in translocation of phosphorylated p47(phox).
There was an increased frequency of the NCF1-339 T allele in patients with systemic lupus erythematosus. The NCF1-339 T allele reduced extracellular ROS (zeige ROS1 Antikörper) production in neutrophils and led to an increase expression of type 1 interferon (zeige IFNA Antikörper)-regulated genes.
Skeletal muscle protein expression of the NADPH oxidase (zeige NOX1 Antikörper) subunits p22(phox (zeige CYBA Antikörper)), p47(phox), and p67(phox (zeige NCF2 Antikörper)) was increased in obese relative to lean subjects, where p22(phox (zeige CYBA Antikörper)) and p67(phox (zeige NCF2 Antikörper)) expression was attenuated by exercise training in obese subjects.
A novel role for Spns2 (zeige SPNS2 Antikörper) and S1P1 (zeige S1PR1 Antikörper)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.
Study provides evidence for a novel PKC-zeta (zeige PRKCZ Antikörper) to p47phox interaction that is required for cell transformation from blebbishields and ROS (zeige ROS1 Antikörper) production in cancer cells.
Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.
A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (zeige NOX1 Antikörper) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population
Data show that diphenylene iodonium (DPI) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS) production by decreasing the translocation and level of NADPH Oxidase p47phox.
Results show that Ncf1 is not needed during juvenility to protect from autoimmune arthritis later on, but conditional Ncf1 suppresses arthritis even if activated after the disease priming. The study presents in vivo evidence that Ncf1/reactive oxygen species-regulated mechanisms are different in priming than in the effector phase.
we used the Ang II (zeige AGT Antikörper) infused hph-1 (zeige EGLN2 Antikörper) mice to examine the roles of NOX isoforms in the development of AAA (zeige AAAS Antikörper). We generated double mutants of hph-1 (zeige EGLN2 Antikörper)-NOX1 (zeige NOX1 Antikörper), hph-1 (zeige EGLN2 Antikörper)-NOX2 (zeige CYBB Antikörper), hph-1 (zeige EGLN2 Antikörper)-p47phox, and hph-1 (zeige EGLN2 Antikörper)-NOX4 (zeige NOX4 Antikörper)
Mice bearing point mutation in the Ncf1-gene develop fewer osteoclasts after ovariectomy (ovx) than wild-type mice. However, irrespective of genotype, bone mineral density decreases after ovx, indicating that a compensatory mechanism retains bone degradation after ovx.
The authors demonstrated a significant role of the host NADPH oxidase (zeige NOX1 Antikörper) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.
data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.
Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (zeige CD4 Antikörper)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.
The Park7 (zeige PARK7 Antikörper) binds to p47(phox), a subunit of the NADPH oxidase (zeige NOX1 Antikörper), to promote NADPH oxidase (zeige NOX1 Antikörper)-dependent production of ROS (zeige ROS1 Antikörper).
p47(phox)-dependent NADPH oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury
p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.
These findings suggest that a p47(phox)-dependent NAD(P)H (zeige NQO1 Antikörper) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.
A p47(phox) and Src kinase (zeige CSK Antikörper) activation of peroxide production by Nox2 (zeige CYBB Antikörper) appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (zeige PKC Antikörper).
Angiotensin II inhibits the Na+/K+ pump via PKC (zeige PKC Antikörper)-dependent activation of NADPH oxidase (zeige NOX1 Antikörper) subunits.
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
47 kDa autosomal chronic granulomatous disease protein
, 47 kDa neutrophil oxidase factor
, NADPH oxidase organizer 2
, SH3 and PX domain-containing protein 1A
, neutrophil NADPH oxidase factor 1
, neutrophil cytosol factor 1
, neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
, nox organizer 2
, nox-organizing protein 2
, NADPH oxidase subunit (47 kD)
, NADPH oxidase subunit (47kDa)
, phagocyte oxidase 47 kDa
, neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1)
, NADPH oxidase p47-phox
, predicted neutrophil cytosolic factor 1