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Data suggest MTMR3 (zeige MTMR3 Proteine) has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 (zeige MTMR3 Proteine) and mTORC1 (MTOR (zeige FRAP1 Proteine), mLST8, raptor (zeige RPTOR Proteine)) which inhibits phosphorylation activity of mTORC1; MTMR3 (zeige MTMR3 Proteine) is localized to Golgi apparatus.
MLST8 upregulation may contribute to tumor progression.
Amino acids promote mTORC1 activation without altering Rag GTP (zeige AK3 Proteine) charging.
MLST8 polymorphism is associated with gastric cancer.
The results obtained indicate that mLST8 bridges between CAD and mTOR (zeige FRAP1 Proteine), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (zeige FRAP1 Proteine) pathway through the association with mLST8.
An essential role of mTORC1 in autophagy inhibition in cell-free system in which, membrane association of Barkor/Atg14(L), a specific autophagosome-binding protein, is suppressed by cytosol from nutrient-rich medium, is shown.
show that E2F1 (zeige E2F1 Proteine) is capable of inducing growth by regulating mTORC1 activity
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin (zeige FRAP1 Proteine) complex 1 and FoxO4 (zeige FOXO4 Proteine)
results suggest that GRp58/ERp57 (zeige PDIA3 Proteine) is involved in the assembly of mTORC1 and positively regulates mTORC1 signaling at the cytosol and the cytosolic side of the endoplasmic reticulum
the crosstalk between AMPK (zeige PRKAA1 Proteine) and mTORC1 signaling is a highly regulated way to control changes in muscle growth and metabolic rate imposed by external cues.
The mutant, Gbeta1(W332A) protein, although inactive, retains its ability to bind Kir3 and prevents the wild type Gbeta (zeige SUCLG2 Proteine) from activating the channel.
cytosolic protein similar to an insulin receptor
Protein LTS8 homolog
, TORC subunit lst8
, protein GbetaL
, target of rapamycin complex subunit lst8
, TORC subunit LST8
, mammalian lethal with SEC13 protein 8
, target of rapamycin complex subunit LST8
, transducin (beta)-like 4
, G beta-like protein