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Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
SIN1 interacted and co-located with PKC zeta (zeige PRKCZ Proteine) by pleckstrin (zeige PLEK Proteine) homology (PH) domain. Downregulation of SIN1 severely impaired PKC zeta (zeige PRKCZ Proteine) translocation and phosphorylation induced by insulin (zeige INS Proteine).
SIN1 plays an important role in breast cancer.
In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 (zeige PDCD4 Proteine) protein was downregulated, suggesting that loss of Pdcd4 (zeige PDCD4 Proteine) might correlate with Sin1 protein level but not mRNA level in colorectal cancer.
SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (zeige FRAP1 Proteine) complex 2 (mTORC2 (zeige CRTC2 Proteine)), is required for Interferon-gamma (zeige IFNG Proteine)-induced phosphorylation and activation of AKT (zeige AKT1 Proteine) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Intracellular localization of mTORC2 (zeige CRTC2 Proteine) component, mSin1, contributes to regulation of Akt (zeige AKT1 Proteine) phosphorylation.
Akt (zeige AKT1 Proteine) phosphorylates SIN1 at T86, enhancing mTORC2 (zeige CRTC2 Proteine) kinase activity, which leads to phosphorylation of Akt (zeige AKT1 Proteine) S473 by mTORC2 (zeige CRTC2 Proteine), thereby catalyzing full activation of Akt (zeige AKT1 Proteine).
MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.
mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
DNA-PKcs (zeige PRKDC Proteine)-mTORC2 (zeige CRTC2 Proteine)(SIN1) association is required for UVB-induced Akt (zeige AKT1 Proteine) Ser (zeige SIGLEC1 Proteine)-473 phosphorylation and cell survival.
analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
data suggest that DNA-PKcs (zeige PRKDC Proteine)-SIN1 complexation-mediated Akt (zeige AKT1 Proteine) activation (Ser (zeige SIGLEC1 Proteine)-473 phosphorylation) is required for mouse osteoblast differentiation
these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.
The phosphorylation of SIN1 by Akt (zeige AKT1 Proteine) was found to regulate mTORC2 (zeige CRTC2 Proteine) activity in response to growth factors, revealing topological insights into the Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling network.
Sin1 and mTORC2 (zeige CRTC2 Proteine) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.
mSIN1 protein mediates SGK1 (zeige SGK1 Proteine) protein interaction with mTORC2 (zeige CRTC2 Proteine) protein complex and is required for selective activation of the epithelial sodium channel
MAP kinase (zeige MAPK1 Proteine)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.
Sin1-mTORC2 (zeige CRTC2 Proteine) suppresses rag1,2 and il7r (zeige IL7R Proteine) gene expression through Akt2 (zeige AKT2 Proteine) in B cells.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.
, Stress-activated protein kinase [SAPK]-interacting protein
, stress-activated map kinase-interacting protein 1
, mitogen-activated protein kinase associated protein 1
, Target of rapamycin complex 2 subunit MAPKAP1
, target of rapamycin complex 2 subunit MAPKAP1-like
, MEKK2-interacting protein 1
, SAPK-interacting protein 1
, TORC2 subunit MAPKAP1
, mitogen-activated protein kinase 2-associated protein 1
, ras inhibitor MGC2745
, stress-activated map kinase interacting protein 1
, stress-activated protein kinase-interacting 1
, target of rapamycin complex 2 subunit MAPKAP1
, mitogen activated protein kinase associated protein 1
, SAPK interacting protein