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In the two wild type (WT) cases, two novel alterations were detected: a complex deletion of APC (zeige APC Proteine) and a pathogenic mutation of LAMTOR2. Focusing on WT DT subtype, deep sequencing of CTNNB1 (zeige CTNNB1 Proteine), APC (zeige APC Proteine) and LAMTOR2 was conducted on a retrospective series of 11 WT DT using a targeted approach
identified polymorphisms in LAMTOR2 and LAMTOR3 (zeige MAPKSP1 Proteine) do not seem to play a relevant role in breast cancer
The ROBLD3 C-A, thorn23 mutation creates a 50SS capable of recruiting an inhibitory U1 snRNP complex leading to a failure of proper 30 end formation and rapid degradation of p14 mRNA.
simulations constitute a multi-dimensional exploration of how EGF (zeige EGF Proteine)-dependent EGFR (zeige EGFR Proteine) endocytosis and ERK (zeige EPHB2 Proteine) activation are dynamically affected by scaffolds KSR (zeige KSR1 Proteine) and MP1 (zeige PITRM1 Proteine), co-regulated by Cbl (zeige CBL Proteine)-CIN85 (zeige SH3KBP1 Proteine) and Endophilin A1 (zeige SH3G2 Proteine)
A complex encoded by the MAPKSP1 (zeige MAPKSP1 Proteine), ROBLD3, and c11orf59 (zeige LAMTOR1 Proteine) genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC.
LAMTOR2 has a role in regulating dendritic cell homeostasis through FLT3 (zeige FLT3 Proteine)-dependent mTOR (zeige FRAP1 Proteine) signalling
Lamtor2 deficiency affects TGFbeta1 (zeige TGFB1 Proteine) sensitivity of Langerhan cells, which is mandatory for their homeostasis and subsequently for their immunological function during contact hypersensitivity.
We show an essential function for late endosomes carrying the p14 (zeige PCOLCE Proteine)-MP1 (zeige MAPKSP1 Proteine) (LAMTOR2/3) complex in focal adhesion dynamics.
The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis.
Data indicate that LAMTOR3 (zeige MAPKSP1 Proteine) protein is stabilized by associating with LAMTOR2.
The late endosomal adaptor p14 (zeige PCOLCE Proteine) (also known as LAMTOR2) is one of the components for cellular host defense against the intracellular pathogen Salmonella enterica serovar Typhimurium.
analysis of interactions between kinase scaffold MP1 (zeige MAPKSP1 Proteine)/p14 (zeige PCOLCE Proteine) and its endosomal anchoring protein p18 (zeige CDKN2C Proteine)
A combination of cell fractionation, two-dimensional gel electrophoresis and mass spectrometry revealed 31 proteins differentially regulated in p14/ organelles, which were rescued by reexpression of pEGFP-p14 in p14/ endosomes
spatial regulation of MAPK signaling, illustrating how p14 and MP1 collaborate as an endosomal adaptor/scaffold complex
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
MAPKSP1 adaptor protein
, endosomal adaptor protein p14
, late endosomal/lysosomal Mp1-interacting protein
, late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
, mitogen-activated protein-binding protein-interacting protein (MAPBPIP)
, ragulator complex protein LAMTOR2
, roadblock domain containing 3
, roadblock domain-containing protein 3
, mitogen-activated protein-binding protein-interacting protein
, late endosomal/lysosomal MP1 interacting protein
, mitogen activated protein binding protein interacting protein
, mitogen-activated protein binding protein interacting protein
, Mitogen-activated protein-binding protein-interacting protein
, Roadblock domain-containing protein 3
, putative mitogen-activated protein-binding protein-interacting protein