GSK3 alpha Proteine (GSK3a)

Human Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. a pivotal role of GSK3 in the maturation of lung progenitors and provide novel insight into proximodistal specification during human lung development, is reported.

2. Here, the authors report that GSK3alpha and GSK3beta are acetylated at Lys246 and Lys183, respectively. They found that SIRT2 deacetylates GSK3beta, and thus enhances its binding to ATP.

3. Mitogen-activated protein kinases and glycogen synthase kinase 3 phosphorylate Gle1A and thereby coordinate stress granule dynamics by altering DDX3 function.

4. These results indicate that GSK3alpha functions as the primary isoform that regulates the expression of IL-10 in endothelial cells infected with S. aureus.

5. GSK-3a and GSK-3b play pivotal roles in hepatocellular carcinoma. (Review)

6. he combined action of CHIR99021 and forskolin markedly delayed neurological deficits and significantly reduced the tumor volume. We suggest that reprogramming technology may be a potential treatment strategy replacing the therapeutic paradigm of traditional treatment of malignant glioma, and a combination molecule comprising a GSK3 inhibitor and a cAMP inducer could be the next generation of anticancer drugs.

7. Using integrated analysis of genome-wide short hairpin RNA (shRNA) screening data in combination with genome-wide gene expression data, the study identified GSK3 as one of the key factors in p53-mediated apoptosis in human lung cancer cells.

8. demonstrated that GSK-3alpha is regulated by CREB in lung cancer and is required for the cell viability. These findings implicate CREB-GSK-3alpha axis as a novel therapeutic target for lung cancer treatment

9. GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction.

10. reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia

11. CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation.

12. Elevated GSK3 protein kinase activity is associated with non-small cell lung carcinoma

13. GSK3A is redundant with GSK3B in regulating drug-resistance and chemotherapy-induced necroptosis

14. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

15. glycogen synthase kinase 3 alpha and beta activity is increased in foetal membranes after term and preterm labour

16. TRAIL-induced apoptosis in pancreatic ductal adenocarcinoma cell lines is enhanced by pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) or by shRNA-mediated depletion of either GSK-3alpha or GSK-3beta.

17. Data indicate that autophagy inhibition promotes glycogen synthase kinase-(GSK3) inhibition-induced apoptosis.

18. PtpA has a role in promoting anti-apoptotic activity of protein-dependent dephosphorylation of host GSK3alpha

19. Protein Kinase B-dependent phosphorylation of glycogen synthase kinase GSK-3 contributes to the pro-fibrotic signaling leading to renal tissue fibrosis in obstructive nephropathy

20. This review highlights the emerging role of GSK3alpha in Alzheimer's disease which has been largely overlooked in favor of GSK3beta.

Mouse (Murine) Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. cAMP, PKA, and GSK3 are interrelated in regulation of sperm function.

2. Testis and sperm are unique in their specific requirement of GSK3alpha for normal function and male fertility.

3. our data describe GSK3 as a novel negative regulator of beta-adrenergic signaling in brown adipocytes.

4. Findings using a mouse model with genetic deletion of Akt3 demonstrate that the specific isoform Akt3 throughout the Akt3/GSK-3 pathway is involved during motor learning.

5. GSK-3 plays a significant role in astrocyte development and behavioral control in mice.

6. Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6)

7. GSK3 is regulated through mechanisms independent of N-terminal serine phosphorylation in order for beta-catenin to be stabilized.

8. The expression of PI3K-insensitive GSK3 stimulates the production of adiponectin and protects from diet-induced metabolic syndrome.

9. Cardiac myocyte GSK-3a is required to maintain normal cardiac homeostasis and loss leads to severe fatal dilated cardiomyopathy.

10. reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia

11. Gsk3 play a role in the maintenance of DNA methylation at a majority of the imprinted loci in embryonic stem cells

12. Sperm GSK3A is essential for male fertility.

13. The absence of oocyte GSK3 isoforms in the periconceptional period does not alter fertility yet causes offspring cardiac hyperplasia, cardiovascular defects, and significant neonatal death.

14. results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the suprachiasmatic nucleus

15. Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure in all areas of the cortex.

16. PI3K/AKT-mediated inhibitory phosphorylation of GSK3 limits the regenerative outcome after peripheral nerve injury.

17. double-knockout embryonic stem cells, as well as GSK-3beta(-/-) mouse embryonic fibroblast cells in which GSK-3alpha was knocked down to demonstrate that both isoforms of GSK-3, GSK-3alpha and GSK-3beta, are required for antiviral immune response.

18. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

19. The two isoforms of GSK-3 are essential integrators of multiple developmental signals that act to maintain normal mammary gland function and suppress tumorigenesis.

20. identify a key role for GSK3 alpha and beta in the regulation of sperm maturation and acrosomal exocytosis

Cow (Bovine) Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. GSK3A serine phosphorylation was positively correlated with embryo development

2. signal pathways converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Pig (Porcine) Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. Seven single-nucleotide polymorphisms, detected in the promoter region of porcine GSK-3alpha gene and carcass traits in Sus scrofa.

2. we demonstrate that PKA, PKC and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A phosphorylation which subsequently controls cell motility.

Zebrafish Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. Results found gsk3a to be a target for miR-34a which downregulates its expression by targeting its 3' UTR. The miR-34a/gsk3a interaction modulates sperm motility in zebrafish.

2. lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta in breast cancer cells.

3. GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival

Xenopus laevis Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. A mechanism whereby LRP6 stabilizes beta-catenin independently of Axin degradation by directly inhibiting GSK3's phosphorylation of beta-catenin, is identified.