GSK3 alpha Proteine (GSK3a)

Human Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. GSK-3a and GSK-3b play pivotal roles in hepatocellular carcinoma. (Review)

2. he combined action of CHIR99021 and forskolin markedly delayed neurological deficits and significantly reduced the tumor volume. We suggest that reprogramming technology may be a potential treatment strategy replacing the therapeutic paradigm of traditional treatment of malignant glioma, and a combination molecule comprising a GSK3 inhibitor and a cAMP inducer could be the next generation of anticancer drugs.

3. Using integrated analysis of genome-wide short hairpin RNA (shRNA) screening data in combination with genome-wide gene expression data, the study identified GSK3 as one of the key factors in p53-mediated apoptosis in human lung cancer cells.

4. demonstrated that GSK-3alpha is regulated by CREB in lung cancer and is required for the cell viability. These findings implicate CREB-GSK-3alpha axis as a novel therapeutic target for lung cancer treatment

5. GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction.

6. reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia

7. CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation.

8. Elevated GSK3 protein kinase activity is associated with non-small cell lung carcinoma

9. GSK3A is redundant with GSK3B in regulating drug-resistance and chemotherapy-induced necroptosis

10. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

11. glycogen synthase kinase 3 alpha and beta activity is increased in foetal membranes after term and preterm labour

12. TRAIL-induced apoptosis in pancreatic ductal adenocarcinoma cell lines is enhanced by pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) or by shRNA-mediated depletion of either GSK-3alpha or GSK-3beta.

13. Data indicate that autophagy inhibition promotes glycogen synthase kinase-(GSK3) inhibition-induced apoptosis.

14. PtpA has a role in promoting anti-apoptotic activity of protein-dependent dephosphorylation of host GSK3alpha

15. Protein Kinase B-dependent phosphorylation of glycogen synthase kinase GSK-3 contributes to the pro-fibrotic signaling leading to renal tissue fibrosis in obstructive nephropathy

16. This review highlights the emerging role of GSK3alpha in Alzheimer's disease which has been largely overlooked in favor of GSK3beta.

17. In lipopolysaccharide-stimulated human neutrophils, GSK-3-alpha inhibitors mimicked the effect of LiCl, by potentiating TNF-alpha release after 4 h. GSK-3 inhibition prolongs activation of the p38/MNK1/eIF4E pathway of mRNA translation.

18. JNK and GSK3 especially are potential signaling molecules regulating BMP-induced osteoblastic human mesenchymal stem cells differentiation.

19. GSK-3 expression and regulation in human neutrophils, was investigated.

20. this studydemonstrated abundant levels of the critical negative cell-cycle regulators, p27(Kip1), its phosphorylated form, p-p27(S10), p18Ink4c, and GSK-3, in beta-cells of both adult human and mouse pancreatic islets, which contribute to maintenance of beta-cell quiescence.

Mouse (Murine) Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. GSK-3 plays a significant role in astrocyte development and behavioral control in mice.

2. Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6)

3. GSK3 is regulated through mechanisms independent of N-terminal serine phosphorylation in order for beta-catenin to be stabilized.

4. The expression of PI3K-insensitive GSK3 stimulates the production of adiponectin and protects from diet-induced metabolic syndrome.

5. Cardiac myocyte GSK-3a is required to maintain normal cardiac homeostasis and loss leads to severe fatal dilated cardiomyopathy.

6. reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia

7. Gsk3 play a role in the maintenance of DNA methylation at a majority of the imprinted loci in embryonic stem cells

8. Sperm GSK3A is essential for male fertility.

9. The absence of oocyte GSK3 isoforms in the periconceptional period does not alter fertility yet causes offspring cardiac hyperplasia, cardiovascular defects, and significant neonatal death.

10. results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the suprachiasmatic nucleus

11. Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure in all areas of the cortex.

12. PI3K/AKT-mediated inhibitory phosphorylation of GSK3 limits the regenerative outcome after peripheral nerve injury.

13. double-knockout embryonic stem cells, as well as GSK-3beta(-/-) mouse embryonic fibroblast cells in which GSK-3alpha was knocked down to demonstrate that both isoforms of GSK-3, GSK-3alpha and GSK-3beta, are required for antiviral immune response.

14. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

15. The two isoforms of GSK-3 are essential integrators of multiple developmental signals that act to maintain normal mammary gland function and suppress tumorigenesis.

16. identify a key role for GSK3 alpha and beta in the regulation of sperm maturation and acrosomal exocytosis

17. GSK3alpha plays a pro-atherogenic role, possibly by mediating the effects of endoplasmic reticulum stress in the activation of pro-atherogenic pathways in high fat diet-fed low density lipoprotein receptor-deficient mice

18. Results show that GSK3alpha rather than GSK3beta is essential for bidirectional synaptic plasticity in the Schaffer collateral to CA1 synapse

19. Coronavirus N phosphorylation by GSK-3 allows recruitment of the RNA helicase DDX1, which facilitates template readthrough and enables longer viral positive-sense single-stranded genomic RNA synthesis.

20. could play a crucial role in renal urine concentration

Cow (Bovine) Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. GSK3A serine phosphorylation was positively correlated with embryo development

2. signal pathways converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Pig (Porcine) Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. Seven single-nucleotide polymorphisms, detected in the promoter region of porcine GSK-3alpha gene and carcass traits in Sus scrofa.

2. we demonstrate that PKA, PKC and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A phosphorylation which subsequently controls cell motility.

Zebrafish Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. Results found gsk3a to be a target for miR-34a which downregulates its expression by targeting its 3' UTR. The miR-34a/gsk3a interaction modulates sperm motility in zebrafish.

2. lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta in breast cancer cells.

3. GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival

Xenopus laevis Glycogen Synthase Kinase 3 alpha (GSK3a) Interaktionspartner

1. A mechanism whereby LRP6 stabilizes beta-catenin independently of Axin degradation by directly inhibiting GSK3's phosphorylation of beta-catenin, is identified.